unsymmetrical α-tertiary dialkyl ethers is reported. By merging Lewis acid-mediated ketal activation and visible-light photocatalytic reduction, in situ-generated α-alkoxy radicals were found to engage in addition reactions with a variety of olefinic partners. Good reaction efficiency is demonstrated with a range of ketals of aromatic and aliphatic ketones. Extension to acetal substrates is also described
报道了构造不对称α-叔二烷基醚的一般光催化还原策略。通过合并
路易斯酸介导的
缩酮活化和可见光光催化还原,发现原位生成的α-烷氧基与多种烯烃伙伴参与了加成反应。一系列芳香族和脂肪族酮的
缩酮证明了良好的反应效率。还描述了对
缩醛底物的扩展,证明了该方法在复杂醚合成中的整体合成效用。