(12R)-acetoxyoleic acid | 45274-92-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (12R)-acetoxyoleic acid
• 英文别名: Oleylacetat；Acetic-oleic anhydride；acetyl (Z)-octadec-9-enoate
• CAS: 45274-92-8
• 化学式: C₂₀H₃₆O₃
• 分子量: 324.504
• InChiKey: GSYXUNSNAIRSOP-KHPPLWFESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  23
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  骨化三醇 、 (12R)-acetoxyoleic acid 在 N,N'-二环己基碳二亚胺 、 4-二甲氨基吡啶 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 14.25h， 生成 (1R,3S,Z)-3-hydroxy-5-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexyl (R,Z)-12-acetoxyoctadec-9-enoate 、 (1S,5R,Z)-5-hydroxy-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2-methylenecyclohexyl (R,Z)-12-acetoxyoctadec-9-enoate
  参考文献：
  名称：

  [EN] LIPID CONJUGATE PREPARED FROM SCAFFOLD MOIETY
  [FR] CONJUGUÉ LIPIDIQUE PRÉPARÉ À PARTIR D'UN FRAGMENT SQUELETTE

  摘要：

  该应用涉及公式M-X1-L的脂质共轭物，其中M是感兴趣的分子，如药物基团；X1是连接基团，如酯、醚或氨基甲酸酯；L是由公式(lId)表示的脂质支架：-L1-[L2(H)(X2R)]n-L3-[L4(H)(X2R)]p-L5-L6，其中L包含5至40个碳原子和0至2个碳-碳双键。该脂质共轭物可以配制在药物传递载体中，如脂质纳米粒子（LNP）。

  公开号：

  WO2020191477A1

文献信息

• Personal care products incorporating cellulosic fatty acid esters
  申请人：Shelton Charles Michael

  公开号：US20070053855A1

  公开（公告）日：2007-03-08

  Cellulose ester compounds and compositions that include such cellulose ester compounds dissolved in lipophilic solvents.

  纤维素酯化合物及包括这种纤维素酯化合物在亲脂溶剂中溶解的组合物。
• Laminated plastic film for food wrapping
  申请人：SHIN-ETSU POLYMER CO., LTD.

  公开号：EP1108531A1

  公开（公告）日：2001-06-20

  Disclosed is a three-layered laminated plastic film consisting of a core layer and two covering layers each bonded to one of the surfaces of the core layer and suitable for wrapping of foods particularly for the wrapping works using a prestretching-type automatic wrapping machine by virtue of the very excellent tensile properties. Characteristically, the core layer is formed from a resin composition comprising an olefin-based thermoplastic elastomer and a hydrogenated petroleum resin with optional admixture of a styrene-based thermoplastic elastomer and/or a low-density polyethylene having a straightly linear molecular structure while the covering layers are formed from a polyethylene-based resin.

  本发明公开了一种三层复合塑料薄膜，该薄膜由一个芯层和两个覆盖层组成，每个覆盖层都粘合在芯层的一个表面上，该薄膜具有非常优异的拉伸性能，适用于食品包装，尤其适用于使用预拉伸型自动包装机的包装工程。芯层由烯烃基热塑性弹性体和氢化石油树脂组成的树脂组合物形成，其中可选择掺入苯乙烯基热塑性弹性体和/或具有直线性分子结构的低密度聚乙烯，而覆盖层则由聚乙烯基树脂形成。
• THERMOPLASTIC CELLULOSE DERIVATIVE COMPOSITION AND FIBER COMPRISING THE SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1335045A1

  公开（公告）日：2003-08-13

  A thermoplastic cellulose derivative composition of the present invention contains, as a main component, a cellulose ester having an aliphatic polyester side chain having a repeat unit having 2 to 5 carbon atoms, wherein a rate of heating loss at 200°C is 5 wt% or less, a melt viscosity at 200°C and 1000 sec-1 is 50 to 300 Pa·sec, and a melt tension at the time of take-up at 200°C and 100 m/min is 0.1 to 40 mN. The present invention can provide excellent fiber products by melt spinning of the composition.

  本发明的一种热塑性纤维素衍生物组合物含有一种纤维素酯作为主要成分，该纤维素酯具有脂肪族聚酯侧链，该侧链的重复单元具有 2 至 5 个碳原子，其中 200°C 时的加热损失率为 5 wt%或更低，200°C 和 1000 sec-1 时的熔体粘度为 50 至 300 Pa-sec，200°C 和 100 m/min 时的卷取熔体张力为 0.1 至 40 mN。本发明可通过对该组合物进行熔融纺丝提供优良的纤维产品。
• ESTER COMPOUND OF CELLULOSE DERIVATIVE AND MANUFACTURING METHOD FOR SAME
  申请人：Riken

  公开号：EP2692738A1

  公开（公告）日：2014-02-05

  The present invention provides a method for manufacturing an ester compound of a cellulose derivative, which suppresses a reduction in the degree of polymerization, and an ester compound of a cellulose derivative obtained from the manufacturing method, which has excellent thermal flowability during molding and color tonality. This method manufactures an ester compound of a cellulose derivative by esterification of a cellulose derivative in a mixture comprising an ionic liquid, a cellulose derivative, and an esterification agent, said method being characterized by the use of at least one type of esterification agent selected from the group consisting of carboxylic acid anhydride, carboxylic acid halide, and carboxylic acid.

  本发明提供了一种可抑制聚合度降低的纤维素衍生物酯类化合物的制造方法，以及一种通过该制造方法获得的纤维素衍生物酯类化合物，该化合物在成型过程中具有优异的热流动性和色调。该方法通过在由离子液体、纤维素衍生物和酯化剂组成的混合物中酯化纤维素衍生物来制造纤维素衍生物的酯化合物，所述方法的特点是使用至少一种从羧酸酐、羧酸卤化物和羧酸组成的组中选出的酯化剂。
• SEPARATION MEMBRANE
  申请人：Toray Industries, Inc.

  公开号：EP3278867A1

  公开（公告）日：2018-02-07

  A problem to be solved by the present invention is to provide a separation membrane having excellent separation performance, having high membrane strength and high permeation performance, and mainly including a cellulose-based resin. The present invention is concerned with a separation membrane including a cellulose ester, having, in the interior thereof, voids each having a specified structure, and having a tensile elasticity of 1,500 to 6,500 MPa.

  本发明要解决的一个问题是提供一种分离性能优异的分离膜，它具有高膜强度和高渗透性能，主要包括纤维素基树脂。本发明涉及一种分离膜，它包括纤维素酯，在其内部，每个空隙都具有特定的结构，并具有 1,500 至 6,500 兆帕的拉伸弹性。