L-alpha-天冬氨酰-L-丙氨酸 | 13433-02-8

• 物质功能分类: 生物化工 - 生化试剂 - 氨基酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-alpha-天冬氨酰-L-丙氨酸
• 英文名称: α-L-aspartyl-L-alanine
• 英文别名: N-L-α-aspartyl-L-alanine；H-α-Asp-Ala-OH；H-Asp-Ala-OH；Asp-Ala；AspAla；Aspartylalanine；(3S)-3-amino-4-[[(1S)-1-carboxyethyl]amino]-4-oxobutanoic acid
• CAS: 13433-02-8
• 化学式: C₇H₁₂N₂O₅
• 分子量: 204.183
• InChiKey: DVUFTQLHHHJEMK-IMJSIDKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• WGK Germany：
  3
• 海关编码：
  2924199090
• 储存条件：
  存储条件：2-8°C，避光保存。

SDS

Version 1.0
Regulation (EC) No 1907/2006

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1 - Product and Company Information

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Product Name ASP-ALA

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2 - Hazards Identification

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3 - Composition/Information on Ingredients

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Product Name CAS # EC no Annex I
Index Number
ASP-ALA 13433-02-8 None None
Formula C7H12N2O5
Molecular Weight 204,2000 AMU

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4 - First Aid Measures

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5 - Fire Fighting Measures

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6 - Accidental Release Measures

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7 - Handling and Storage

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STORAGE
Store at -20°C

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8 - Exposure Controls / Personal Protection

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9 - Physical and Chemical Properties

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pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
SIGMA www.molbase.com
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A

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10 - Stability and Reactivity

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11 - Toxicological Information

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12 - Ecological Information

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No data available.

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13 - Disposal Considerations

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14 - Transport Information

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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

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15 - Regulatory Information

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Caution: Substance not yet fully tested (EU).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

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16 - Other Information

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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
SIGMA www.molbase.com
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMA www.molbase.com

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

H-Asp-Ala-OH是己二酸的一种衍生物。

反应信息

• 作为反应物：
  描述：

  L-alpha-天冬氨酰-L-丙氨酸 在 soybean cotyledon N-terminal acidic amino acid-specific aminopeptidase 作用下， 生成 L-丙氨酸 、 L-天门冬氨酸
  参考文献：
  名称：

  Purification and Characterization of an N-Terminal Acidic Amino Acid-Specific Aminopeptidase from Soybean Cotyledons (Glycine max)

  摘要：

  通过硫酸铵分级和 Q-sepharose、Phenyl sepharose 和 Superdex 200 连续柱层析，从大豆子叶中分离出一种催化 Glu-Glu 高效水解的新型酶。该酶的表观分子量为 56 kDa分别通过 SDS-聚丙烯酰胺凝胶电泳和 Superdex 200 HR 10/30 柱层析得出 510 kDa 和 510 kDa。该酶对 Glu-p-硝基苯胺 (pNA) 和 Asp-pNA 具有高活性，而 Leu-pNA、Phe-pNA、Ala-pNA 和 Pro-pNA 不被水解。合成的二肽 Glu-Xxx 和 Asp-Xxx 被水解，但 Xxx-Glu 没有被水解。使用这种纯化酶消化富含 Glu 的寡肽嗜铬粒蛋白 A (Glu-Glu-Glu-Glu-Glu-Met-Ala-Val-Val-Pro-Gln-Gly-Leu-Phe-Arg-Gly-NH2)也被调查。谷氨酸残基从N末端一一被切割。这些观察结果表明该酶从 N 末端含酸性氨基酸的肽中去除谷氨酰或天冬氨酰残基。人们认为它是一种来自植物的 N 末端酸性氨基酸特异性氨肽酶。

  DOI：

  10.1271/bbb.90617
• 作为产物：
  描述：

  N-Benzyloxycarbonyl-β-benzylaspartylalaninbenzylester 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 生成 L-alpha-天冬氨酰-L-丙氨酸
  参考文献：
  名称：

  Baba,T. et al., Chemical and pharmaceutical bulletin, 1973, vol. 21, p. 207 - 209

  摘要：

  DOI：

文献信息

• Peptide sequencing: The utility of chemical ionization mass spectrometry
  作者：M. Mudgett、D. V. Bowen、F. H. Field、T. J. Kindt

  DOI：10.1002/bms.1200040308

  日期：1977.6

  Chemical ionization mass spectrometry is used at low resolution to determine the sequences of permethylated acetyl peptides. The method has been tested with 45 peptides, between 2 and 5 residues long, including examples of all of the common amino acids except cysteine and N-terminal asparagine. The isobutane chemical ionization spectra contain three principal types of N-terminal sequence ion and one

  化学电离质谱法以较低的分辨率用于确定过甲基化乙酰基肽的序列。该方法已经用45个肽进行了测试，长度在2至5个残基之间，包括除半胱氨酸和N末端天冬酰胺以外的所有常见氨基酸的实例。异丁烷化学电离光谱包含三种主要类型的N端序列离子和一种C端序列离子。从这四种类型的序列离子中可获得的冗余信息提高了序列确定的可靠性。展望未来，异丁烷化学电离质谱法似乎是确定肽序列的有用技术，在某些情况下可能具有优势。
• Studies on peptides. 103. Chemical synthesis of a crystalline protein with the full enzymic activity of ribonuclease A
  作者：Haruaki Yajima、Nobutaka Fujii

  DOI：10.1021/ja00409a040

  日期：1981.9
• METHOD FOR TREATMENT OF CANCERS OR INFLAMMATORY DISEASES
  申请人：Oy Reagena Ltd

  公开号：EP2155237A2

  公开（公告）日：2010-02-24
• GLYCOSYLASPARAGINASE FOR TREATMENT OF CANCER
  申请人：Oy Reagena Ltd

  公开号：EP2155237B1

  公开（公告）日：2016-02-10
• Topically applicable cosmetic/dermatological compositions comprising hydrolase polypeptides having amidase activity and/or products modulating the activity thereof
  申请人：SOCIETE L'OREAL, S.A.

  公开号：US20040197299A1

  公开（公告）日：2004-10-07

  Hydrolase polypeptides having amidase activity and products capable of modulating the activity thereof are well suited for the treatment of, inter alia, dry skins and/or the signs of skin aging and/or for combating skin desquamation.

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