水杨酸-C8-水杨酸 | 74134-02-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 水杨酸-C8-水杨酸
• 英文名称: salicylic acid-C8-salicylic acid
• 英文别名: 2-[8-(2-Carboxyphenoxy)-8-oxooctanoyl]oxybenzoic acid；2-[8-(2-carboxyphenoxy)-8-oxooctanoyl]oxybenzoic acid
• CAS: 74134-02-4
• 化学式: C₂₂H₂₂O₈
• 分子量: 414.412
• InChiKey: YVWLCAGDPHYGCS-UHFFFAOYSA-N

物化性质

• 熔点：
  141-143 °C
• 沸点：
  634.5±50.0 °C(Predicted)
• 密度：
  1.308±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  水杨酸-C8-水杨酸 、 乙酸酐 以66.8%的产率得到suberoyl bis-salicylic acid-acetic acid mixed anhydride
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR THE INHIBITION OF BONE GROWTH AND RESORPTION
  [FR] COMPOSITIONS ET PROCEDES D'INHIBITION DE CROISSANCE ET DE RESORPTION OSSEUSE

  摘要：

  公开号：

  WO2005039489A3
• 作为产物：
  描述：

  1,8-二辛酰氯 、 水杨酸 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 0.75h， 生成 水杨酸-C8-水杨酸
  参考文献：
  名称：

  High molecular wegiht polymers, devices and method for making and using same

  摘要：

  无水酐聚合物释放活性或可激活的药剂，具有预选特性，如分子量、柔韧性、硬度、粘附性等其他有价值的特性。这些聚合物适用于在一段时间内控制释放药剂的组合物、配方、涂层、设备等，这些产品受益于药剂的控制释放。这些聚合物是通过涉及各种替代和连续步骤的过程制备的，这些步骤允许事先设计具有特定特性的产品。这些聚合物适合作为传递系统，可以单独使用，也可以作为组合物、配方或设备。

  公开号：

  US20050048121A1

文献信息

• Effect of Linker Structure on Salicylic Acid-Derived Poly(anhydride−esters)
  作者：Almudena Prudencio、Robert C. Schmeltzer、Kathryn E. Uhrich

  DOI：10.1021/ma048051u

  日期：2005.8.1

  A series of salicylic acid-derived poly(anhydride -esters) were synthesized by melt polymerization methods, in which the structures of the molecule ("linker") linking together the two salicylic acids were varied. To determine the relationship between the linker and the physical properties of the corresponding poly(anhydride-ester), several linkers were evaluated including linear aliphatic, aromatic, and aliphatic branched structures. For the linear aliphatic linkers, higher molecular weights were obtained with longer linear alkyl chains. The most sterically hindered linkers yielded lower molecular weight polymers. The thermal decomposition temperature increased with the alkyl chain length, but the glass transition temperature decreased, due to the enhanced flexibility of the polymer. The highest glass transition temperatures were obtained by using aromatic linkers as a result of inereased pi-pi interactions. Water contact angles determined the relative hydrophobicity of the polymers, which correlated to hydrolytic degradation rates; i.e., the highest contact angle values yielded the slowest degrading polymers.
• Nitric oxide releasing polymers
  申请人：Kalivretenos G. Aristotle

  公开号：US20070196327A1

  公开（公告）日：2007-08-23

  This invention relates to compositions comprising carbon-based diazeniumdiolates attached to hydrophobic polymers that releases nitric oxide (NO). The carbon-based diazeniumdiolated polymers release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated polymers, compositions comprising such polymers, methods of using such compositions, and devices employing such polymer compositions
• COMPOUNDS, POLYMERS AND METHODS FOR TREATING GASTROINTESTINAL DYSFUNCTION
  申请人：Kalivretenos Aristotle G.

  公开号：US20100255062A1

  公开（公告）日：2010-10-07

  The present disclosure describes novel carbon-based diazeniumdiolates agents and compounds or salts or prodrugs thereof that release nitric oxide for the treatment of neuropathic gastrointestinal dysfunction. The neuropathic gastrointestinal dysfunction refers to disorders associated with motility, sensation and neuromuscular function that include but are not limited to conditions such as delayed gastric emptying.
• [EN] NITRIC OXIDE-RELEASING POLYMERS<br/>[FR] POLYMERES LIBERANT DE L'OXYDE NITRIQUE
  申请人：AMULET PHARMACEUTICALS INC

  公开号：WO2007067477A1

  公开（公告）日：2007-06-14

  [EN] This invention relates to compositions comprising carbon-based diazeniumdiolates attached to hydrophobic polymers that releases nitric oxide (NO). The carbon-based diazeniumdiolated polymers release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated polymers, compositions comprising such polymers, methods of using such compositions, and devices employing such polymer compositions
  [FR] La présente invention concerne des compositions comprenant des diazéniumdiolates à base de carbone liés à des polymères hydrophobes libérant de l'oxyde nitrique (NO). Les polymères diazéniumdiolatés à base de carbone libèrent du NO spontanément dans des conditions physiologiques sans formation subséquente de nitrosamine. La présente invention concerne également des procédés de fabrication de ces polymères diazéniumdiolatés à base de carbone, des compositions comprenant de tels polymères, des procédés d'utilisation de telles compositions et des dispositifs utilisant de telles compositions polymériques.
• High molecular wegiht polymers, devices and method for making and using same
  申请人：East Anthony

  公开号：US20050048121A1

  公开（公告）日：2005-03-03

  Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.

  无水酐聚合物释放活性或可激活的药剂，具有预选特性，如分子量、柔韧性、硬度、粘附性等其他有价值的特性。这些聚合物适用于在一段时间内控制释放药剂的组合物、配方、涂层、设备等，这些产品受益于药剂的控制释放。这些聚合物是通过涉及各种替代和连续步骤的过程制备的，这些步骤允许事先设计具有特定特性的产品。这些聚合物适合作为传递系统，可以单独使用，也可以作为组合物、配方或设备。