4-甲氧基-3-甲氧基吗啉 | 61020-09-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 4-甲氧基-3-甲氧基吗啉
• 中文别名: 4-甲酰基-3-甲氧基吗啉
• 英文名称: 3-methoxymorpholine-4-carbaldehyde
• 英文别名: 3-methoxy-4-formylmorpholine；N-formyl-3-methoxymorpholine；4-formyl-3-methoxy-morpholine；N-Formyl-3-methoxymorpholin
• CAS: 61020-09-5
• 化学式: C₆H₁₁NO₃
• mdl: MFCD09859660
• 分子量: 145.158
• InChiKey: WTPRBRLPWZIBJW-UHFFFAOYSA-N

物化性质

• 沸点：
  264.26°C (rough estimate)
• 密度：
  1.2511 (rough estimate)
• 稳定性/保质期：
  避免接触水

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 安全说明：
  S24/25
• 海关编码：
  2934999090
• 储存条件：
  在密封的贮藏器中存放，并置于阴凉、干燥处。

SDS

Name:	N-Formyl-3-Methoxy-Morpholine, 95% Material Safety Data Sheet
Synonym:	None known.
CAS:	61020-09-5

Section 1 - Chemical Product MSDS Name: N-Formyl-3-Methoxy-Morpholine, 95% Material Safety Data Sheet
Synonym: None known.

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SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
61020-09-5	N-Formyl-3-Methoxy-Morpholine	95	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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SECTION 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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SECTION 4 - FIRST AID MEASURES
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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SECTION 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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SECTION 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

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SECTION 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 61020-09-5: Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: clear, colorless
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H11NO3
Molecular Weight: 145.16

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SECTION 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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SECTION 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 61020-09-5 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
N-Formyl-3-Methoxy-Morpholine - Not listed by ACGIH, IARC, or NTP.

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SECTION 12 - ECOLOGICAL INFORMATION

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SECTION 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations.

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SECTION 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material.

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SECTION 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 61020-09-5: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 61020-09-5 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 61020-09-5 is not listed on the TSCA inventory. It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
MSDS Creation Date: 9/02/1997 Revision #4 Date: 3/18/2003 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-甲氧基-3-甲氧基吗啉 在 三氟甲磺酸 作用下， 以 氯仿 为溶剂， 反应 0.5h， 以92%的产率得到2,3-dihydro-[1,4]oxazine-4-carbaldehyde
  参考文献：
  名称：

  Confirmation by trapping, synthesis, and reactivity of 2,3-dehydro-N-methylmorpholine (DNMM)

  摘要：

  The elusive 4-methyl-3,4-dihydro-2H-[1,4] oxazine (2,3-dehydro-N-methylmorpholine, DNMM, 5) was confirmed to occur as degradation product of N-methylmorpholine-N-oxide (1) by trapping with the alpha-tocopherol-derived ortho-quinone methide in a hetero-Diels-Alder reaction with inverse electron demand. The regioselectivity of the addition was in good agreement with DFT computational data. An authentic sample of 5 was synthesized from formmorpholide (16) via 2-methoxy-formmorpholide in 38% overall yield. (c) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2007.09.055
• 作为产物：
  描述：

  甲醇 、 N-甲酰吗啉 在 tetrabutylammonium tetrafluoroborate 作用下， 以67%的产率得到4-甲氧基-3-甲氧基吗啉
  参考文献：
  名称：

  吡咯烷-1-甲醛的高效流动电化学烷氧基化

  摘要：

  我们报告了使用新型电化学微反应器优化 Nformylpyrrolidine 的烷氧基化。精确控制反应条件允许以高产率合成单烷氧基化或二烷氧基化反应产物。

  DOI：

  10.1055/s-0037-1611774

文献信息

• Palasz, Peter D.; Utley, James H. P.; Hardstone, J. David, Journal of the Chemical Society. Perkin transactions II, 1984, # 4, p. 807 - 814
  作者：Palasz, Peter D.、Utley, James H. P.、Hardstone, J. David

  DOI：——

  日期：——
• Eberson, Lennart; Malmberg, Mats; Nyberg, Klas, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1983, vol. 37, # 6, p. 555 - 566
  作者：Eberson, Lennart、Malmberg, Mats、Nyberg, Klas

  DOI：——

  日期：——
• Enzymatic resolution of cyclic N-Boc protected β-aminoacids
  作者：Cyrille Pousset、Roland Callens、Mansour Haddad、Marc Larchevêque

  DOI：10.1016/j.tetasy.2004.09.022

  日期：2004.11

  Methyl and ethyl esters of N-Boc homoproline, homopipecolic acid and 3-carboxymethyl-morpholine were kinetically resolved by hydrolysis catalysed by Burkholderia cepacia lipase to give the corresponding acids and residual esters in enantiomeric excesses better than 99% (E > 100). (C) 2004 Published by Elsevier Ltd.
• Nyberg,K.; Servin,R., Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1976, vol. 30, p. 640 - 642
  作者：Nyberg,K.、Servin,R.

  DOI：——

  日期：——
• Eberson, Lennart; Malmberg, Mats; Nyberg, Klas, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1984, vol. 38, # 5, p. 345 - 350
  作者：Eberson, Lennart、Malmberg, Mats、Nyberg, Klas

  DOI：——

  日期：——