methyl 2-amino-4-(nitromethyl)-4H-chromene-3-carboxylate | 1111277-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: methyl 2-amino-4-(nitromethyl)-4H-chromene-3-carboxylate
• CAS: 1111277-66-7
• 化学式: C₁₂H₁₂N₂O₅
• 分子量: 264.238
• InChiKey: FSLGZCOLNXHLDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  硝基甲烷 、 水杨醛 、 氰乙酸甲酯 在 PbS nanoparticles stabilized on hyperbranched polyglycerol modified silica coated FeNi₃ 作用下， 反应 0.01h， 以93%的产率得到methyl 2-amino-4-(nitromethyl)-4H-chromene-3-carboxylate
  参考文献：
  名称：

  PbS nanoparticles stabilized on HPG-modified FeNi3 as catalyst for synthesis of 2-amino-4H-chromene under mild conditions

  摘要：

  FeNi3\SiO2\HPG\PbS 磁性纳米颗粒（MNPs）催化剂是通过廉价起始材料在水相中易于制备的，该催化剂通过间歇性微波辐照催化合成 2-氨基-4H-色烯。采用X射线衍射、透射电子显微镜和扫描电子显微镜对合成的 FeNi3\SiO2\HPG\PbS MNPs 的性质进行了表征。该催化系统具有高催化活性以及通过外部磁场从反应混合物中易于回收，并且在多次重复使用后性能没有显著损失，显示出其额外的环保特性。

  DOI：

  10.1007/s13738-013-0388-0

文献信息

• Experimental and Theoretical Investigation of One-pot Synthesis of 2-Amino-4H-chromenes Catalyzed by Basic-functionalized Ionic Liquids
  作者：Yuanyuan Wang、Yuetong Wu、Yu Wang、Liyi Dai

  DOI：10.1002/cjoc.201200181

  日期：2012.8

  efficient and environmentally benign procedure for the reactions of three components condensation of salicylaldehyde and two different CH acids to give 2‐amino‐4H‐chromenes catalyzed by a series of basic‐functionalized ionic liquids was reported. The most possible reaction pathway was proposed for the first time by performing density functional theory (DFT) calculations. Both cation and anion of [Bmim]OH

  报道了一种有效的，对环境有益的方法，该方法可用于水杨醛和两种不同的CH酸的三组分缩合反应，得到一系列碱性官能化离子液体催化的2-氨基-4 H-色烯。通过执行密度泛函理论（DFT）计算，首次提出了最可能的反应途径。[Bmim] OH的阳离子和阴离子均对反应具有协同作用。[BMIM] +通过分子间氢键增加水杨醛的亲电性，而OH -剥夺质子2个CH酸以加强它们的亲核能力。
• Catalysis of Salicylaldehydes and Two Different<i>CH</i>Acids with Electricity: First Example of an Efficient Multicomponent Approach to the Design of Functionalized Medicinally Privileged 2-Amino-4<i>H</i>-Chromene Scaffold
  作者：Michail N. Elinson、Alexander S. Dorofeev、Fedor M. Miloserdov、Alexey I. Ilovaisky、Sergey K. Feducovich、Pavel A. Belyakov、Gennady I. Nikishin

  DOI：10.1002/adsc.200700493

  日期：2008.3.7

  synthesized. The electrocatalytic process was found to be advantageous in terms of selectivity and yields compared to classic chemical base catalysis, and includes a remarkable mechanistic feature that is promising for the further development of 2-amino-4H-chromene chemistry. The application of this convenient electrocatalytic multicomponent method to the formation of medicinally relevant 2-amino-4H-chromenes

  在溴化钠作为电解质的存在下，在未分裂的细胞中，通过电化学诱导的水杨醛和两种不同的CH酸在醇中的多组分转化，可在65中有效和选择性地形成功能多样的，医学上享有特权的2-氨基-4 H-亚甲基支架–86％的收益率。发达的电催化系统根据其反应性区分了两种CH酸，并为2-氨基-4 H提供了一种有效的方法-具有所需取代基的预定排列的色烯支架。电催化多组分反应可同时与带有给电子基团和吸电子基团的水杨醛一起进行。因此，已经合成了十五种肿瘤拮抗剂HA14-1和MX58151的先前难以接近的，紧密的结构类似物。与经典的化学碱催化方法相比，发现电催化方法在选择性和收率方面是有利的，并且包括显着的机理特征，有望进一步发展2-氨基-4 H-色烯化学。这种方便的电催化多组分方法在药物相关的2-氨基-4 H的形成中的应用从面向多样性的大规模方法的角度看，二甲基苯酮也是有益的，代表了多组分反应策略的新颖，简便且对环境无害的合成概念。
• Solvent-free cascade reaction: direct multicomponent assembling of 2-amino-4H-chromene scaffold from salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes
  作者：Michail N. Elinson、Alexey I. Ilovaisky、Valentina M. Merkulova、Pavel A. Belyakov、Alexander O. Chizhov、Gennady I. Nikishin

  DOI：10.1016/j.tet.2010.04.024

  日期：2010.6

  The new type of solvent-free cascade reaction was found: the direct heating of the mixture of salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes at 60 degrees C in the presence of catalytic amounts of KF or NaOAc results in the formation of 2-amino-4-(1-nitroalkyl)-4H-chromene-3-carbonitriles or methyl 2-amino-4-(1-nitroalkyl)-4H-chromene-3-carboxylates in 30-90% yields. Thus, the new simple and efficient solvent-free 'one-pot' way to substituted medicinally privileged 2-amino-4H-chromene scaffold was found directly from such simple and reasonable starting compounds as salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes. (C) 2010 Elsevier Ltd. All rights reserved.
• PbS nanoparticles stabilized on HPG-modified FeNi3 as catalyst for synthesis of 2-amino-4H-chromene under mild conditions
  作者：Seyed Mohsen Sadeghzadeh、Mohammad Ali Nasseri

  DOI：10.1007/s13738-013-0388-0

  日期：2014.8

  FeNi3\SiO2\HPG\PbS magnetic nanoparticles (MNPs) catalyst was readily prepared from inexpensive starting materials in aqueous media which catalyzed the synthesis 2-amino-4H-chromene via intermittent microwave irradiation. X-ray diffraction, transmission electron micrographs, and scanning electron micrographs were employed to characterize the properties of the synthesized FeNi3\SiO2\HPG\PbS MNPs. High catalytic activity and ease of recovery from the reaction mixture using external magnet and several reuse times without significant losses in performance are additional eco-friendly attributes of this catalytic system.

  FeNi3\SiO2\HPG\PbS 磁性纳米颗粒（MNPs）催化剂是通过廉价起始材料在水相中易于制备的，该催化剂通过间歇性微波辐照催化合成 2-氨基-4H-色烯。采用X射线衍射、透射电子显微镜和扫描电子显微镜对合成的 FeNi3\SiO2\HPG\PbS MNPs 的性质进行了表征。该催化系统具有高催化活性以及通过外部磁场从反应混合物中易于回收，并且在多次重复使用后性能没有显著损失，显示出其额外的环保特性。