N-辛基单氧乙烯 | 10020-43-6

• 物质功能分类: 化学试剂 - 有机试剂 - 烯烃（环状与无环状）
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: N-辛基单氧乙烯
• 中文别名: n-辛基-单氧乙烯；乙二醇单辛醚
• 英文名称: 2-octyloxyethanol
• 英文别名: octyloxy ethanol；ethylene glycol 1-O-octyl ether；ethylene glycol monooctyl ether；ethylene glycol monooctylether；ethylene glycol octyl ether；2-(1-octyloxy)-1-ethanol；2-(Octyloxy)ethanol；2-octoxyethanol
• CAS: 10020-43-6
• 化学式: C₁₀H₂₂O₂
• 分子量: 174.283
• InChiKey: ZQCIMPBZCZUDJM-UHFFFAOYSA-N

物化性质

• 熔点：
  -69.1°C (estimate)
• 沸点：
  241℃
• 密度：
  0.880 g/mL at 20 °C(lit.)
• 闪点：
  66℃
• 溶解度：
  0.01 M
• 保留指数：
  1282;1287.1
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R19,R36/38
• WGK Germany：
  3
• 海关编码：
  2909499000
• 安全说明：
  S24/25,S28
• 储存条件：
  存放于-20℃阴凉干燥处

SDS

Name:	n-Octyl-monooxyethylene Material Safety Data Sheet
Synonym:	Ethylene glycol monooctyl ether; C8E1; 2-(Octyloxy)ethanol
CAS:	10020-43-6

Section 1 - Chemical Product MSDS Name:n-Octyl-monooxyethylene Material Safety Data Sheet
Synonym:Ethylene glycol monooctyl ether; C8E1; 2-(Octyloxy)ethanol

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
10020-43-6	n-Octyl-monooxyethylene	100	233-015-8

Hazard Symbols: XI
Risk Phrases: 19 36/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
May form explosive peroxides. Irritating to eyes and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May cause digestive tract disturbances. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. May form explosive peroxides.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Purge container with nitrogen before resealing. Keep dry.
Store in a cool, dry, well-ventilated area away from incompatible substances. Deep freeze (below -20C). Containers should be dated when opened and tested periodically for the presence of peroxides.
Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals. All peroxidizable substances should be stored away from heat and light and be protected from ignition sources.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 10020-43-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: clear - colorless
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 72 deg C @ .30 mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 106 deg C ( 222.80 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Insoluble.
Specific Gravity/Density: .8800g/cm3
Molecular Formula: C10H22O2
Molecular Weight: 174.30

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Under normal storage conditions, peroxidizable compounds can form and accumulate peroxides which may explode when subjected to heat or shock. This material is most hazardous when peroxide levels are concentrated by distillation or evaporation.
Conditions to Avoid:
Evaporating to near dryness, prolonged exposure to air.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, peroxides.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 10020-43-6 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
n-Octyl-monooxyethylene - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 19 May form explosive peroxides.
R 36/38 Irritating to eyes and skin.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
WGK (Water Danger/Protection)
CAS# 10020-43-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 10020-43-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 10020-43-6 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N-辛基单氧乙烯 在 咪唑 、 四溴化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 生成 2-bromoethyl n-octyl ether
  参考文献：
  名称：

  Anchor Dependency for Non-Glycerol Based Cationic Lipofectins: Mixed Bag of Regular and Anomalous Transfection Profiles

  摘要：

  Although detailed structure activity, physicochemical and biophysical investigations in probing the anchor influence in liposomal gene delivery have been reported for glycerol-based transfection lipids, the corresponding investigation for non-glycerol based simple monocationic transfection lipids have not yet been undertaken. Towards this end, herein, we delineate our structure - activity and physicochemical approach in deciphering the anchor dependency in liposomal gene delivery using fifteen new structural analogues (lipids 1 - 15) of recently reported nonglycerol based monocationic transfection lipids. The C-14 analogues in both series 1 (lipids 1 - 6) and series 2 (lipids 7-15) showed maximum efficiency in transfecting COS-1 and CHO cells. However, the C-12 analogue of the ether series (lipid 3) exhibited a seemingly anomalous behavior compared with its transfection efficient C-10 and C-14 analogues (lipids 2 and 4) in being completely inefficient to transfect both COS-1 and CHO cells. The present structure - activity investigation also convincingly demonstrates that enhancement of transfection efficiencies through incorporation of membrane reorganizing unsaturation elements in the hydrophobic anchor of cationic lipids is not universal but cell dependent. The strength of the interaction of lipids 1 - 15 with DNA was assessed by their ability to exclude ethidium bromide bound to the DNA. Cationic lipids with long hydrophobic tails were found, in general, to be efficient in excluding EtBr from DNA. Gel to liquid crystalline transition temperatures of the lipids was measured by fluorescence anisotropy measurement technique. In general (lipid 2 being an exception), transfection efficient lipids were found to have their mid transition temperatures at or below physiological temperatures (37degreesC).

  DOI：

  10.1002/1521-3765(20020215)8:4<900::aid-chem900>3.0.co;2-x
• 作为产物：
  描述：

  乙二醇 以83.3的产率得到N-辛基单氧乙烯
  参考文献：
  名称：

  DP-b99的合成方法

  摘要：

  本发明涉及DP-b99的合成方法，包括将邻硝基苯酚A和碳酸钾加入溶剂中溶解，加入1，2-二溴乙烷得B；将B溶于溶剂中并加入高压釜在钯碳氢气环境下，加热反应得C；将C与二异丙基丙胺、碘化钠、溴乙酸乙脂在乙腈中混合，在氮气保护下，在80～90℃回流反应得D；将D加入乙醇中，滴加氢氧化钾的水溶液，室温下反应，pH2-4，析出E；将E加入到含吡啶的乙酸酐中，加热反应至完全，加乙醚，沉淀为F；室温下将钠加入乙二醇中，滴加1-溴辛烷，加热反应，加水，乙醚萃取得I；将F与I混合，加热反应加乙醚，静置，沉淀为DP-b99。优点是：还原硝基采取氢化法，反应清洁、便于操作、收率较高；用碘化钠和缚酸剂，使反应易进行，收率提高。

  公开号：

  CN102030670A
• 作为试剂：
  描述：

  1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid anhydride 、 N-辛基单氧乙烯 在 N-辛基单氧乙烯 作用下， 以39.2的产率得到N,N'-[1,2-乙基双(氧-2,1-苯基)]双[N-(羧甲基)甘氨酸 1,1'-双[2-(辛氧基)乙基]酯
  参考文献：
  名称：

  WO1999016741A2

  摘要：

  公开号：

文献信息

• Molecular design of the electron-donating sidearm of lariat ethers: effective coordination of the quinoline moiety in complexation toward alkali-metal cations
  作者：Yohji. Nakatsuji、Tetsuya. Nakamura、Masayuki. Yonetani、Hajime. Yuya、Mitsuo. Okahara

  DOI：10.1021/ja00210a037

  日期：1988.1

  La propriete de coordination specifique du reste quinoleine (bras lateral du lariat) est etudiee en mesurant l'aptitude complexante dans le methanol a 25°C

  La propriete de Coordination specifique du reste quinoleine (braslateral du lariat) est etudiee en mesurant l'aptitude complexante dans le甲醇 a 25°C
• Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP1170275A3

  公开（公告）日：2004-04-14

  Normally liquid, omega-hydrofluoroalkyl ether compounds (and selected mixtures thereof) have a saturated perfluoroaliphatic chain of carbon atoms interrupted by one or more ether oxygen atoms. The compounds can be prepare, e.g. by decarboxylation of the corresponding fluoroalkyl ether carboxylic acids and are useful, e.g., in cleaning and drying applications.

  通常是液体的ω-氢氟烷基醚化合物（及其选定的混合物）具有由一个或多个醚氧原子中断的饱和全氟脂肪链的碳原子。这些化合物可以通过相应的氟烷基醚羧酸的脱羧反应制备，例如在清洁和干燥应用中很有用。
• 新的1,2-顺式木糖苷表面活性剂
  申请人：湘潭大学

  公开号：CN106883276A

  公开（公告）日：2017-06-23

  本发明公开了一种木糖衍生的1,2‑顺式的新型糖苷表面活性剂及其应用。采用D‑木糖为原料，通过酰化、偶联及脱保护三步反应，得到1,2‑顺式的烷氧基乙基‑ɑ‑D‑吡喃木糖苷。该类表面活性剂能充分转化农作物下脚料所获取的D‑木糖，生产成本低廉，制备方法简单，产物环境友好。该糖苷水溶性改善，表面活性较强，发泡性和乳化性能可选可控，作为表面活性剂具有良好的市场前景和经济价值。
• Oxidative degradation of oligo(ethylene glycol)-terminated monolayers
  作者：Guoting Qin、Chengzhi Cai

  DOI：10.1039/b911155g

  日期：——

  The observation that oligo(ethylene glycol) (OEG)-terminated monolayers remained highly protein-resistant for a month at 37 °C in PBS buffer while they degraded faster in air can be rationalized by a proposed mechanism formulated from a model study using the first internal hydroperoxide of OEG.

  观察到以低聚（乙二醇）（OEG）端接的单分子层在37°C的PBS缓冲液中保持高度抗蛋白性达一个月，而在空气中降解更快，这一现象可以通过一个基于使用OEG第一个内氢过氧化物的模型研究提出的机制来合理化。
• Highly Efficient Stereoselective Catalytic C(sp³)H Insertions with Donor Rhodium Carbenoids Generated from Cyclopropenes
  作者：Alexis Archambeau、Frédéric Miege、Christophe Meyer、Janine Cossy

  DOI：10.1002/anie.201205913

  日期：2012.11.12

  Rings of five and six: Donor alkenyl rhodium carbenoids generated from 3,3‐dimethylcyclopropenylcarbinols exhibit high reactivity in intramolecular CH insertions. The reactions proceed under remarkably mild conditions, tolerate the presence of the free hydroxy group, and afford an efficient and stereoselective access to a variety of functionalized carbocycles and oxygen heterocycles.

  的五和六环：从3,3- dimethylcyclopropenylcarbinols产生供体链烯基铑卡宾表现出在分子内1C高反应性 ħ插入。反应在非常温和的条件下进行，可以容忍游离羟基的存在，并且可以高效，立体选择性地进入各种功能化的碳环和氧杂环。

表征谱图