N1,n4-二(buta-2,3-二enyl)丁烷-1,4-二胺双盐酸盐

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N1,n4-二(buta-2,3-二enyl)丁烷-1,4-二胺双盐酸盐
• 中文别名: N1,N4-二(BUTA-2,3-二ENYL)丁烷-1,4-二胺双盐酸盐
• 英文名称: N,N'-bis(buta-2,3-dienyl)butane-1,4-diamine;hydron;dichloride
• 化学式: C12H22Cl2N2
• 分子量: 265.22
• InChiKey: ITVRWVVFVHINOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.47
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.1
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• N1,N4-BIS(BUTA-1,3-DIENYL)BUTANE-1,4-DIAMINE PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：Wisconsin Alumini Research Foundation

  公开号：EP2026782A2

  公开（公告）日：2009-02-25
• N1,N4-bis(buta-1,3-dienyl)butane-1,4-diamine pharmaceutical compositions and methods thereof
  申请人：Basu Hirak S.

  公开号：US20080114072A1

  公开（公告）日：2008-05-15

  N1,N4-bis(buta-1,3-dienyl)butane-1,4-diamine dihydrochloride (also referred to as MDL 72,527 and N,N′-di-2,3-butadienyl-1,4-butanediamine dihydrochloride), or salts or solvates thereof, its use as an antioxidant, its use in preventing and/or treating prostate cancer in male humans, and its use in reducing the concentration of reactive oxygen species in human prostate gland tissue or any other body tissue, and methods of making the compound thereof. Other methods include inhibiting acetyl polyamine oxidase in human prostate tissue or other human body tissue comprising administering a therapeutic amount of N,N′-bis(2,3-butadienyl)-1,4-butanediamine or a salt or solvate thereof to the human, and a method of determining oxidative stress in human prostate tissue or other human or animal body tissue comprising measuring a ratio of oxidized 2′,7′-dichlorodihydrofluorescein diacetate fluorescence:DNA fluorescence and hydroethidine dye fluorescence ex vivo or in vivo.
• N1,N4-BIS(BUTA-1,3-DIENYL)BUTANE-1,4-DIAMINE PHARMACEUTICAL COMPOSITIONS AND METHODS THEREOF
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20140179798A1

  公开（公告）日：2014-06-26

  N1,N4-bis(buta-1,3-dienyl)butane-1,4-diamine dihydrochloride (also referred to as MDL 72,527 and N,N′-di-2,3-butadienyl-1,4-butanediamine dihydrochloride), or salts or solvates thereof, its use as an antioxidant, its use in preventing and/or treating prostate cancer in male humans, and its use in reducing the concentration of reactive oxygen species in human prostate gland tissue or any other body tissue, and methods of making the compound thereof are disclosed. Other disclosed methods include inhibiting acetyl polyamine oxidase in human prostate tissue or other human body tissue comprising administering a therapeutic amount of N,N′-bis(2,3-butadienyl)-1,4-butanediamine or a salt or solvate thereof to the human, and a method of determining oxidative stress in human prostate tissue or other human or animal body tissue comprising measuring a ratio of oxidized 2′,7′-dichlorodihydrofluorescein diacetate fluorescence:DNA fluorescence and hydroethidine dye fluorescence ex vivo or in vivo.
• [EN] N1,N4-BIS(BUTA-1,3-DIENYL)BUTANE-1,4-DIAMINE PHARMACEUTICAL COMPOSITIONS AND METHODS THEREOF<br/>[FR] COMPOSITIONS PHARMACEUTIQUES DE LA N1,N4-BIS(BUTA-1,3-DIÉNYL)BUTANE-1,4-DIAMINE ET PROCÉDÉS D'UTILISATION ET DE FABRICATION DE CELLES-CI
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2007130589A2

  公开（公告）日：2007-11-15

  [EN] N1,N4-bis(buta-1,3-dienyl)butane-1,4-diamine dihydrochloride (also referred to as MDL 72,527 and N,N'-di-2,3-butadienyl-1,4-butanediamine dihydrochloride), or salts or solvates thereof, its use as an antioxidant, its use in preventing and/or treating prostate cancer in male humans, and its use in reducing the concentration of reactive oxygen species in human prostate gland tissue or any other body tissue, and methods of making the compound thereof. Other methods include inhibiting acetyl polyamine oxidase in human prostate tissue or other human body tissue comprising administering a therapeutic amount of N,N'-bis(2,3-butadienyl)-1,4-butanediamine or a salt or solvate thereof to the human, and a method of determining oxidative stress in human prostate tissue or other human or animal body tissue comprising measuring a ratio of oxidized 2',7'-dichlorodihydrofluorescein diacetate fluorescence :DNA fluorescence and hydroethidine dye fluorescence ex vivo orin vivo.
  [FR] L'invention concerne dichlorhydrate de N1,N4-bis(buta-1,3-diényl)butane-1,4-diamine (également appelé MDL 72 527 et dichlorhydrate de N,N'-di-2,3-butadiényl-1,4-butanediamine) ou ses sels ou ses solvates; son utilisation en tant qu'antioxydant, son utilisation pour prévenir et/ou traiter le cancer de la prostate chez des êtres humains mâles et son utilisation pour réduire la concentration d'espèces réactives de l'oxygène dans le tissu de la prostate humaine ou n'importe quel autre tissu du corps humain; et les procédés de fabrication du composé. D'autres procédés comprennent un procédé consistant à inhiber l'acétylpolyamine oxydase dans le tissu de la prostate humaine ou d'autres tissus du corps humain consistant à administrer à l'être humain une quantité thérapeutique de N,N'-bis(2,3-butadiényl)-1,4-butanediamine ou d'un sel ou solvate de celle-ci et un procédé de détermination du stress oxydatif dans le tissu de la prostate humaine ou d'autres tissus du corps humain ou animal consistant à mesurer ex vivo ou in vivo le rapport (fluorescence du diacétate de 2',7'-dichlorodihydrofluorescéine oxydé):(fluorescence de l'ADN et fluorescence du colorant hydroéthidine).
• [EN] NL, N4-BIS (BUTA-I, 3-DIENYL) BUTANE-I, 4-DIAMINE PHARMACEUTICAL COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS PHARMACEUTIQUES DE LA N1,N4-BIS(BUTA-1,3-DIÉNYL)BUTANE-1,4-DIAMINE ET PROCÉDÉS D'UTILISATION ET DE FABRICATION DE CELLES-CI
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2007130589A3

  公开（公告）日：2008-03-27

  [EN] N1,N4-bis(buta-1,3-dienyl)butane-1,4-diamine dihydrochloride (also referred to as MDL 72,527 and N,N'-di-2,3-butadienyl-1,4-butanediamine dihydrochloride), or salts or solvates thereof, its use as an antioxidant, its use in preventing and/or treating prostate cancer in male humans, and its use in reducing the concentration of reactive oxygen species in human prostate gland tissue or any other body tissue, and methods of making the compound thereof. Other methods include inhibiting acetyl polyamine oxidase in human prostate tissue or other human body tissue comprising administering a therapeutic amount of N,N'-bis(2,3-butadienyl)-1,4-butanediamine or a salt or solvate thereof to the human, and a method of determining oxidative stress in human prostate tissue or other human or animal body tissue comprising measuring a ratio of oxidized 2',7'-dichlorodihydrofluorescein diacetate fluorescence :DNA fluorescence and hydroethidine dye fluorescence ex vivo orin vivo.
  [FR] L'invention concerne dichlorhydrate de N1,N4-bis(buta-1,3-diényl)butane-1,4-diamine (également appelé MDL 72 527 et dichlorhydrate de N,N'-di-2,3-butadiényl-1,4-butanediamine) ou ses sels ou ses solvates; son utilisation en tant qu'antioxydant, son utilisation pour prévenir et/ou traiter le cancer de la prostate chez des êtres humains mâles et son utilisation pour réduire la concentration d'espèces réactives de l'oxygène dans le tissu de la prostate humaine ou n'importe quel autre tissu du corps humain; et les procédés de fabrication du composé. D'autres procédés comprennent un procédé consistant à inhiber l'acétylpolyamine oxydase dans le tissu de la prostate humaine ou d'autres tissus du corps humain consistant à administrer à l'être humain une quantité thérapeutique de N,N'-bis(2,3-butadiényl)-1,4-butanediamine ou d'un sel ou solvate de celle-ci et un procédé de détermination du stress oxydatif dans le tissu de la prostate humaine ou d'autres tissus du corps humain ou animal consistant à mesurer ex vivo ou in vivo le rapport (fluorescence du diacétate de 2',7'-dichlorodihydrofluorescéine oxydé):(fluorescence de l'ADN et fluorescence du colorant hydroéthidine).