7-methoxy-3-(4-fluorophenyl)-4'-methoxyflavone-8-acetic acid | 1571899-96-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 7-methoxy-3-(4-fluorophenyl)-4'-methoxyflavone-8-acetic acid
• 英文别名: 2-[3-(4-Fluorophenyl)-7-methoxy-2-(4-methoxyphenyl)-4-oxochromen-8-yl]acetic acid；2-[3-(4-fluorophenyl)-7-methoxy-2-(4-methoxyphenyl)-4-oxochromen-8-yl]acetic acid
• CAS: 1571899-96-1
• 化学式: C₂₅H₁₉FO₆
• 分子量: 434.421
• InChiKey: FIOJQHZIUMSIKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-氟苯乙酸 在 吡啶 、 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 硫酸 、 三氟化硼乙醚 、 水 、 potassium carbonate 、 溶剂黄146 作用下， 以 四氯化碳 、 二氯甲烷 、 丙酮 、 甘油 为溶剂， 反应 21.5h， 生成 7-methoxy-3-(4-fluorophenyl)-4'-methoxyflavone-8-acetic acid
  参考文献：
  名称：

  Synthesis, selective cytotoxicities and probable mechanism of action of 7-methoxy-3-arylflavone-8-acetic acids

  摘要：

  Thirteen new analogues of flavone-8-acetic acid, that is, compounds 10a-m bearing a methoxy group at the 7-position and diverse subsitiuents on the benzene ring at the 2- and 3-positions of flavone nucleus, were synthesized and evaluated for their direct antiproliferative effects on two human tumor cell lines and for their indirect antiproliferative activities in the transwell co-culture system. The results indicated that most of compounds 10a-m showed moderate direct cytotoxicities. Among them, compound 10i exhibited higher direct cytotoxicity and selectivity for both cell lines over BJ human foreskin fibroblast cells than 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Interestingly, compared with DMXAA, compound 10e showed comparable indirect cytotoxicity and higher selectivity. In addition, compound 10e was found to be able to induce tumor necrosis factor alpha (TNF-alpha) production in human peripheral blood mononuclear cells. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.01.042

文献信息

• Synthesis, selective cytotoxicities and probable mechanism of action of 7-methoxy-3-arylflavone-8-acetic acids
  作者：Zhong-Zhen Zhou、Chun-Ping Gu、Yan-Hong Deng、Guang-Hua Yan、Xiao-Fang Li、Le Yu、Wen-Hua Chen、Shu-Wen Liu

  DOI：10.1016/j.bmc.2014.01.042

  日期：2014.3

  Thirteen new analogues of flavone-8-acetic acid, that is, compounds 10a-m bearing a methoxy group at the 7-position and diverse subsitiuents on the benzene ring at the 2- and 3-positions of flavone nucleus, were synthesized and evaluated for their direct antiproliferative effects on two human tumor cell lines and for their indirect antiproliferative activities in the transwell co-culture system. The results indicated that most of compounds 10a-m showed moderate direct cytotoxicities. Among them, compound 10i exhibited higher direct cytotoxicity and selectivity for both cell lines over BJ human foreskin fibroblast cells than 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Interestingly, compared with DMXAA, compound 10e showed comparable indirect cytotoxicity and higher selectivity. In addition, compound 10e was found to be able to induce tumor necrosis factor alpha (TNF-alpha) production in human peripheral blood mononuclear cells. (C) 2014 Elsevier Ltd. All rights reserved.