Bis (trichloromethyl) sulfone appears as an off-white powdered solid with an aromatic odor. Contact may irritate skin, eyes or mucous membranes. May be toxic by ingestion, inhalation or skin absorption. Used to make other chemicals.
颜色/状态：
Off white
气味：
Pungent aromatic
蒸汽压力：
3.1X10-3 mm Hg at 25 °C (est)
分解：
When heated to decomposition it emits very toxic fumes of /hydrogen chloride and sulfur oxides/.
/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/
/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/
/LABORATORY ANIMALS: Acute Exposure/ The oral LD50 for bis(trichloromethyl) sulfone (N-1386 Biocide) in male rats was 691 mg/kg. Deaths occurred 1-5 days after treatment and signs of toxicity suggestive of an anticholinesterase effect were noted. However, neither plasma cholinesterase nor brain acetylcholinesterase was inhibited 2, 4 or 24 hours after a single, oral dose of 500 mg/kg. Atropine (300 mg/kg, sc) or scopolamine (670 mg/kg, sc) pretreatments did not protect against the acute lethality of bis(trichloromethyl) sulfone although signs of toxicity were alleviated by both pretreatments. Bis(trichloromethyl) sulfone produced in vitro inhibition of rat plasma cholinesterase and brain acetylcholinesterase. The inhibition was competitive in brain. IC50's for these 2 enzymes were 8 uM in plasma and 25 uM in brain. In summary, bis(trichloromethyl) sulfone produced in vitro cholinesterase inhibition not demonstrated in vivo. Doses of anticholinergic compounds that ameliorated many toxic signs did not protect against lethality produced by bis(trichloromethyl) sulfone.
/LABORATORY ANIMALS: Acute Exposure/ N-1386 purity not stated) at a dose of 500 mg/kg was administered via a single oral gavage to male adult Sprague-Dawley rats (number not stated). In vivo plasma and brain cholinesterase activity were measured 2, 4 and 24 hours after dosing. There was no significant inhibition of either cholinesterase compared with untreated controls. In vitro effects were measured at 0, 5, 10 and 50 uM added directly to rat plasma. There was almost complete inhibition at 50 uM. N- 1386 was added to brain homogenates at 0, 1, 5 or 10 uM. There was a concentration dependent inhibition at 5 and 10 uM. The effect of anti-cholinergic drugs (atropine and scopolamine) on mortality when administered just prior to N-1386 treatment (505, 600, 713, 848 or 1,008 mg/kg) to 10 male rats/group was studied. Neither compound significantly increased the LD50 or the time to death. Atropine did, however, reduce the incidence of diarrhea and scopolamine reduced the incidence of both diarrhea and behavioral depression.
PHYTOSANITARY COMPOSITIONS COMPRISING AN ETHER-AMIDE COMPOUND
申请人：RHODIA OPERATIONS
公开号：US20150208645A1
公开（公告）日：2015-07-30
The object of the present invention is phytosanitary compositions comprising an active phytosanitary product and an ether-amide compound. The ether-amide compound may natively be present as a solvent, co-solvent, crystallization inhibitor or an agent for increasing bioactivity of the active phytosanitary product.
Disclosed is a method of inhibiting the growth of microorganisms in, at, or on a locus subject to microbial attack, comprising introducing to said locus an antimicrobially effective amount of at least one alkoxy disulfide of formula:R1-CHR3-O-S-S-O-CHR4-R2 wherein:
R1, R2are independently selected from 5- or 6-membered aromatic rings, optionally substituted with up to 3 e· donating substituents of which 2 can optionally be combined to form another ring; and
R3, R4are independently selected from H, CH3, or CH2CH3.
[EN] COMPOSITIONS HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO<br/>[FR] COMPOSITIONS AYANT UNE UTILITÉ PESTICIDE ET PROCÉDÉS ASSOCIÉS
申请人：DOW AGROSCIENCES LLC
公开号：WO2021158455A1
公开（公告）日：2021-08-12
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses a molecule having the following formula and mixtures thereof.
Metal complexes, the preparation thereof and use as biocides
申请人：IMPERIAL CHEMICAL INDUSTRIES PLC
公开号：EP0392648A1
公开（公告）日：1990-10-17
A metal complex of the general formula
[R1CSNRO]xM(L)y
where R and R1 are optionally substituted hydrocarbyl groups, M is a metal of Group IIIA to VA and IB to VIIB, with the exception of copper, L is a ligand, x has a value of 1 to 3 and y is zero or has a value of up to 4. The complex may be prepared by the reaction of a metal salt with an N-hydroxythiobenzamide. Complexes of this type have anti-microbial properties, and can be used as industrial biocides.
USE OF MULTIPLE CHARGED CATIONIC COMPOUNDS DERIVED FROM PRIMARY AMINES OR POLYAMINES FOR MICROBIAL FOULING CONTROL IN A WATER SYSTEM
申请人：ECOLAB USA INC.
公开号：US20200068885A1
公开（公告）日：2020-03-05
Disclosed herein are the methods of using specific di-cationic or multiple charged cationic compounds, which are derived from primary amine or polyamines through an aza-Michael addition with an α, β-unsaturated carbonyl compound or from polyamines through both an aza-Michael addition with an α, β-unsaturated carbonyl compound and a ring-opening reaction with an epoxide, in a fouling control composition to reduce microbial and/biofilm growth in a water system. The disclosed methods or compositions are found to be more effective than those methods or compositions including commonly used single quaternary compounds for reducing microbial or biofilm growth in water systems.
