唐松草碱 | 5373-42-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 中文名称: 唐松草碱
• 英文名称: Thalicarpine
• 英文别名: (6aS)-9-[2-[[(1S)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-4,5-dimethoxyphenoxy]-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
• CAS: 5373-42-2
• 化学式: C₄₁H₄₈N₂O₈
• 分子量: 696.8
• InChiKey: ZCTJIMXXSXQXRI-KYJUHHDHSA-N

物化性质

• 熔点：
  160-161°
• 比旋光度：
  D25 +133° (c = 0.83 in methanol); D25 +89° (c = 0.88 in chloroform)
• 沸点：
  701.43°C (rough estimate)
• 密度：
  1.1544 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  51
• 可旋转键数：
  11
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• Compounds and compositions for treating infection
  申请人：Chepkwony Paul Kiprono

  公开号：US20090069277A1

  公开（公告）日：2009-03-12

  Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.

  来自14种肯尼亚植物的化合物，包括 Dovyalis abyssinica 和 Clutia robusta 的根部已经被鉴定和分离，它们的用途也被公开了。
• COMPOUNDS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：Chepkwony Paul Kiprono

  公开号：US20120190734A1

  公开（公告）日：2012-07-26

  Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.

  来自14种肯尼亚植物的化合物已经被鉴定和分离，包括来自阿比西尼亚多维亚利斯和强健小簇花的根部，它们的用途已经被披露。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Mutagenic evaluation method
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0273771A2

  公开（公告）日：1988-07-06

  A method for evaluating the potential mutagenic activity of a substance which comprises: (a) culturing cytochrome P-450 induced bacteria from the genus Streptomyces in a culture medium comprising the substance to be evaluated; (b) incubating an amino acid requiring mutant strain of Salmonella typhimurium in the presence of a sample of the bacterial culture from (a); and (c) determining the number of resulting amino acid sufficient revertant colonies.

  一种评估物质潜在诱变活性的方法，包括 (a) 在含有待评估物质的培养基中培养链霉菌属的细胞色素 P-450 诱导菌； (b) 在有(a)中的细菌培养物样本存在的情况下，培养鼠伤寒沙门氏菌的氨基酸需要突变菌株；以及 (c) 确定所产生的氨基酸充足变异菌落的数量。
• Process for inducing cytochrome p-450 enzymes in streptomyces bacteria and determining the mutagenicity of chemicals
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0347226A1

  公开（公告）日：1989-12-20

  A method of evaluating the potential mutagenic activity of a substance which comprises: (a) forming a test culture, comprising a first culture medium, the substance to be evaluated, and cytochrome P-450 induced bacteria from the genus Streptomyces, which bacteria contain a plasmid which comprises a gene, which, upon exposure to a substance having mutagenic activity, confers to said bacteria the ability to grow in the presence of a preselected marker material; (b) forming a control culture, comprising the cytochrome P-450 induced bacteria of step (a) and the culture medium of step (a) without the substance to be evaluated; (c) separately harvesting the bacteria from the test culture and the control culture; (d) separately culturing the harvested test bacteria and control bacteria under conditions which promote the formation of spores from said bacteria to form test spores and control spores; (e) separately culturing the test spores and control spores in a second culture medium which (i) promotes the formation of bacteria from said spores and (ii) comprises the marker material; (f) separately determining the fraction of the bacteria formed from the test spores and control spores which have the ability to grow in the presence of the preselected marker material, thereby determining a test revertant rate and a control revertant rate; (g) determining the ratio of the test revertant rate to the control revertant rate; and (h) determining that said substance has mutagenic activity whenever the ratio of step (g) is at least about 1.9.

  一种评估物质潜在诱变活性的方法，包括 (a) 形成试验培养物，其中包括第一种培养基、待评估物质和链霉菌属的细胞色素 P-450 诱导细菌，该细菌含有质粒，该质粒包含一个基因，当暴露于具有致突变活性的物质时，该基因赋予所述细菌在预选标记物存在下生长的能力； (b) 形成对照培养物，包括步骤(a)的细胞色素 P-450 诱导细菌和步骤(a)的培养基，其中不含待评估物质； (c) 分别从试验培养物和对照培养物中收获细菌； (d) 在促进所述细菌形成孢子的条件下，分别培养收获的试验细菌和对照细菌，以形成 试验孢子和对照孢子； (e) 在第二种培养基中分别培养试验孢子和对照孢子，第二种培养基(i) 能促进所述孢子形成细菌，(ii) 包含标记材料； (f) 分别确定由试验孢子和对照孢子形成的细菌中在预选标记材料存在下具有生长能力的部分，从而确定试验返祖率和对照返祖率； (g) 确定试验逆转率与对照逆转率的比率；以及 (h) 只要步骤(g)中的比率至少为约 1.9，则确定所述物质具有诱变活性。