1,4-苯二氧杂环乙烷-6-腈 | 19102-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 中文名称: 1,4-苯二氧杂环乙烷-6-腈
• 中文别名: 苯并二氧六环-6-甲腈；2,3-二氢-1,4-苯并二噁英-6-甲腈
• 英文名称: 2,3-dihydrobenzo[b][1,4]dioxine-6-carbonitrile
• 英文别名: 2,3-dihydro-1,4-benzodioxine-6-carbonitrile；1,4-benzodioxane-6-carbonitrile
• CAS: 19102-07-9
• 化学式: C₉H₇NO₂
• mdl: MFCD00221462
• 分子量: 161.16
• InChiKey: JGSRMKGBXNXODT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  42.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2932999099
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

SDS

Name:	2 3-Dihydro-1 4-benzodioxine-6-carbonitrile Material Safety Data Sheet
Synonym:	None Known
CAS:	19102-07-9

Section 1 - Chemical Product MSDS Name:2 3-Dihydro-1 4-benzodioxine-6-carbonitrile Material Safety Data Sheet
Synonym:None Known

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
19102-07-9	2,3-Dihydro-1,4-benzodioxine-6-carboni	97+%	unlisted

Hazard Symbols: XN
Risk Phrases: 20/21/22 36/37/38

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. Harmful if absorbed through the skin. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Metabolism may release cyanide, which may result in headache, dizziness, weakness, collapse, unconsciousness and possible death.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation. May be metabolized to cyanide which in turns act by inhibiting cytochrome oxidase impairing cellular respiration.
Chronic:
Exposure to small amounts of cyanide compounds over long periods of time is reported to cause loss of appetite, headache, weakness, nausea, dizziness, and symptoms of irritation of the upper respiratory tract and eyes.

---

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 19102-07-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Off white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 104 - 106 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C9H7NO2
Molecular Weight: 161.16

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents, reducing agents.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 19102-07-9 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,3-Dihydro-1,4-benzodioxine-6-carbonitrile - Not listed by ACGIH, IARC, or NTP.

---

Section 12 - ECOLOGICAL INFORMATION

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: NITRILES, TOXIC, N.O.S.
Hazard Class: 6.1
UN Number: 3276
Packing Group: III
IMO
Shipping Name: NITRILES, TOXIC, N.O.S.
Hazard Class: 6.1
UN Number: 3276
Packing Group: III
RID/ADR
Shipping Name: NITRILES, TOXIC, N.O.S.
Hazard Class: 6.1
UN Number: 3276
Packing group: III

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 22 Do not breathe dust.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 19102-07-9: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 19102-07-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 19102-07-9 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1,4-苯二氧杂环乙烷-6-腈 在 硫酸 、 三氟乙酸 、 水 作用下， 反应 5.0h， 以74%的产率得到苯并二氧六环-6-甲酰胺
  参考文献：
  名称：

  o-Acylbenzonitriles: Synthesis and Heterocyclization under Acid Hydrolysis of the Cyano Group

  摘要：

  2-Cyanobenzophenones were synthesized by reaction of 2-bromobenzophenones with copper(I) cyanide in DMF, and their transformations involving acid hydrolysis of the cyano group were studied. Reactions of o-benzoylbenzonitriles with trifluoroacetic acid in the presence or in the absence of sulfuric acid afforded 3-hydroxyphthalimidines in high yields. Under analogous conditions, benzonitriles having no acyl group in the ortho position were converted to the corresponding benzamides. 2-Cyanobenzophenones reacted with sulfuric acid in the absence of trifluoroacetic acid to give only substituted anthraquinones.

  DOI：

  10.1134/s1070428018030065
• 作为产物：
  描述：

  2,3-二氢-1,4-苯并二恶烷-6-羰酰氯 在 4-二甲氨基吡啶 、 palladium diacetate 、 三乙胺 、 二苯基环己基膦 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 16.0h， 生成 1,4-苯二氧杂环乙烷-6-腈
  参考文献：
  名称：

  钯催化酰胺的脱羰氰化

  摘要：

  过渡金属催化的芳基卤化物氰化是制备药物，有机材料和农药的重要过程。在这里，我们通过高选择性的碳-氮键裂解展示了钯催化的酰胺的脱羰氰化氰化物，用于合成各种芳基腈。同位素标记的芳基腈的合成和稳固酰胺的正交交叉偶联反应可建立具有相反极性的交叉偶联合成子，从而证明了该技术的实用性。

  DOI：

  10.1021/acs.orglett.7b01199

文献信息

• HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles
  作者：Sagar R. Mudshinge、Chinmay S. Potnis、Bo Xu、Gerald B. Hammond

  DOI：10.1039/d0gc00757a

  日期：——

  HCl·DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl·DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional

  我们报告了一种有效的HCl·DMPU辅助将一锅法将醛转化为腈的方法。将HCl·DMPU用作酸性来源和非亲核碱均构成制备腈的环境温和的替代方法。我们的操作规程顺利进行，无需使用有毒的试剂和金属催化剂。结合了各种官能团的各种官能化的芳香族，脂肪族和烯丙基醛已成功地以优异的定量转化为腈。该协议的特点是底物范围广，反应条件温和，可扩展性高。
• Hepatitis C virus inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US09527885B2

  公开（公告）日：2016-12-27

  Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

  揭示了具有一般式（I）的丙型肝炎病毒抑制剂。还公开了包含这些化合物的组合物以及使用这些化合物抑制HCV的方法。
• Stable and reusable nanoscale Fe₂O₃-catalyzed aerobic oxidation process for the selective synthesis of nitriles and primary amides
  作者：Kathiravan Murugesan、Thirusangumurugan Senthamarai、Manzar Sohail、Muhammad Sharif、Narayana V. Kalevaru、Rajenahally V. Jagadeesh

  DOI：10.1039/c7gc02627g

  日期：——

  nitriles and amides from easily available starting materials using cost-effective catalysts and green reagents is highly desired. In this regard, herein we report the nanoscale iron oxide-catalyzed environmentally benign synthesis of nitriles and primary amides from aldehydes and aqueous ammonia in the presence of 1 bar O2 or air. Under mild reaction conditions, this iron-catalyzed aerobic oxidation process

  在腈纶或酰胺基团形式的功能化分子中可持续引入氮基是至关重要的，因为在许多生命科学分子，天然产物和材料中都发现了含氮基序。因此，非常需要使用具有成本效益的催化剂和绿色试剂从容易获得的起始原料合成腈和酰胺的方法。就这一点而言，本文报道了在1 bar O 2的存在下，由醛和氨水进行的纳米级氧化铁催化的腈和伯酰胺的环境友好合成。或空气。在温和的反应条件下，该铁催化的需氧氧化过程继续进行，以合成功能化且结构多样的芳族，脂族和杂环腈。另外，应用该铁基方案，还已经在水介质中制备了伯酰胺。
• Design, synthesis and evaluation of novel hybrids between 4-anilinoquinazolines and substituted triazoles as potent cytotoxic agents
  作者：Giang Le-Nhat-Thuy、Thuy Van Dinh、Hai Pham-The、Hung Nguyen Quang、Nga Nguyen Thi、Tuyet Anh Dang Thi、Phuong Hoang Thi、Tu Anh Le Thi、Ha Thanh Nguyen、Phuong Nguyen Thanh、Trung Le Duc、Tuyen Van Nguyen

  DOI：10.1016/j.bmcl.2018.10.016

  日期：2018.12

  dioxygenated ring fused 4-anilinoquinazolines (10a-d) and 4-anilinoquinazoline-substituted triazole hybrid compounds (11–14) have been designed and synthesized. Their biological significance was highlighted by evaluating in vitro for anticancer activities, wherein several compounds displayed excellent activity specifically against three human cancer cell lines (KB, epidermoid carcinoma; HepG2, hepatoma

  在此研究了几个系列新颖二氧化环的稠合的4-苯胺（10A-d ）和4-苯胺基-取代的三唑杂化化合物（11 - 14）已经被设计和合成。通过体外评估其抗癌活性突出了它们的生物学意义，其中几种化合物显示出针对三种人类癌细胞系（KB，表皮样癌； HepG2，肝癌； SK-Lu-1，非小细胞肺癌）的优异活性。特别地，与厄洛替尼相比，化合物13a显示出高达100倍的更高的细胞毒性。对接最具细胞毒性的化合物（11d，13a，13b，和14c）插入不同EGFR酪氨酸激酶结构域的ATP结合位点，以预测这些化合物与EGFR靶标的类似结合模式。
• 一种制备腈类化合物的氰化方法
  申请人：中国科学院兰州化学物理研究所苏州研究院

  公开号：CN108017557B

  公开（公告）日：2020-11-24

  本发明提供一种制备腈类化合物的氰化方法，将有机卤化物或拟卤化物与廉价易得的CO2、NH3及还原剂反应，在过渡金属催化剂的存在下发生选择性氰化反应，获得目标产物有机腈类化合物。在本发明中使用了一种全新的反应路线，通过金属催化CO2和NH3的反应，“一锅法”直接实现卤化物及拟卤化物的脱(拟)卤氰化，避免了传统氰基化反应需要用到当量剧毒氰化物的问题，同时提供了一种直接、方便的新方法制备同位素标记的腈类化合物，可以用于医学、示踪、生物学和药物研发中。