2'-羟基-2,4,4-三甲基黄烷 | 5026-12-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 2'-羟基-2,4,4-三甲基黄烷
• 英文名称: 2-(2-hydroxyphenyl)-2,4,4-trimethylchroman
• 英文别名: 2'-hydroxy-2,4,4-trimethylflavan；2-(2,4,4-Trimethyl-chroman-2-yl)-phenol；(2,4,4-trimethyl-chroman-2-yl)phenol；2'-Hydroxy-2,4,4-trimethyl-flavan；2-(2,4,4-trimethyl-3H-chromen-2-yl)phenol
• CAS: 5026-12-0
• 化学式: C₁₈H₂₀O₂
• 分子量: 268.356
• InChiKey: DCXUDDFJZAJGAG-UHFFFAOYSA-N

物化性质

• 熔点：
  97 °C
• 沸点：
  390.9±42.0 °C(Predicted)
• 密度：
  1.087±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于二氯甲烷、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2'-羟基-2,4,4-三甲基黄烷 在 palladium on activated charcoal sodium hydroxide 、 氢气 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 2,4,4-trimethylchromane
  参考文献：
  名称：

  Nowakowska; Daszkiewicz; Kyziol, Polish Journal of Chemistry, 1996, vol. 70, # 12, p. 1542 - 1549

  摘要：

  DOI：
• 作为产物：
  描述：

  2-phenoxypropene 在 盐酸 、 硫酸 作用下， 生成 2'-羟基-2,4,4-三甲基黄烷
  参考文献：
  名称：

  Baker et al., Journal of the Chemical Society, 1952, p. 1774,1785

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR PRODUCING BISPHENOL-A<br/>[FR] PROCÉDÉ DE FABRICATION DU BISPHÉNOL-A
  申请人：SABIC INNOVATIVE PLASTICS IP

  公开号：WO2010004371A1

  公开（公告）日：2010-01-14

  A process for preparing 2,2-bis(4-hydroxyphenyl)propane (p,p-bisphenol-A) from2,4,4-trimethyl-2-(4-hydroxyphenyl)chroman (chroman 1.5) is disclosed. Phenol andchroman 1.5 are contacted over an acidic ion exchange resin at a given temperature for agiven period of time. The process results in improved quality of p,p-bisphenol-A, betterperformance of catalyst, improved raw material usage, and reduced waste.

  本发明公开了一种从2,4,4-三甲基-2-(4-羟基苯基)色基苷(chroman 1.5)制备2,2-双(4-羟基苯基)丙烷(p,p-双酚A)的方法。在给定温度下，将苯酚和chroman 1.5通过酸性离子交换树脂接触一定时间。该过程能够提高p,p-双酚A的质量，提高催化剂的性能，改善原材料的使用和减少废弃物。
• Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
  申请人：Chao J. Hannguang

  公开号：US20050267119A1

  公开（公告）日：2005-12-01

  The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y 1 receptor activity.

  本发明提供了新型吡啶基或苯基脲及其类似物，它们是人类P2Y1受体的选择性抑制剂。本发明还提供了各种相应的制药组合物和调节P2Y1受体活性的治疗疾病的方法。
• UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS
  申请人：Chao Hannguang J.

  公开号：US20080280905A1

  公开（公告）日：2008-11-13

  The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y 1 receptor activity.

  本发明提供了新型吡啶基或苯基脲及其类似物，它们是选择性的人类P2Y1受体抑制剂。本发明还提供了各种该类药物组成物和调节P2Y1受体活性以治疗对其反应的疾病的方法。
• Process for production of 2,2-bis(4-hydroxyphenyl) propane
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0112615A2

  公开（公告）日：1984-07-04

  A process for continuously producing 2,2-bis(4-hydroxyphenyl) propane having a high quality from a reaction of phenol and acetone in the presence of a hydrochloric acid containing catalyst comprising the steps of: (A) carrying out the reaction by continuously charging additional phenol, the below-mentioned circulating phenol, additional acetone, additional hydrogen chloride or hydrochloric acid, the below-mentioned circulating oily mother liquor, and the below-mentioned aqueous mother liquid into a reactor to form a reaction mixture slurry comprising the crude phenol adduct of 2,2-bis(4-hydroxyphenyl) propane in the form of crystal and two liquid phase reaction mother liquors of an oily mother liquor and an aqueous mother liquor; (B) separating the reaction mixture slurry into the crude phenol adduct of 2,2-bis(4-hydroxyphenyl) propane and the two liquid phase mother liquors after discharging the reaction mixture slurry from the reactor; (C) separating the two liquid phase mother liquors obtained in the above-mentioned step (B) into the oily mother liquor and the aqueous mother liquor, whereby the oily mother liquor is circulated as a circulating oily mother liquor to the reactor and the remaining portion of the aqueous mother liquor, after discharging a portion thereof, is circulated as a circulating aqueous mother liquor to the reactor; (D) dissolving the crude phenol adduct of 2,2-bis(4-hydroxyphenyl) propane obtained in the above-mentioned step (B) in a phenol solvent and, after neutralizing the hydrogen chloride or hydrochloric acid contained in the crude phenol adduct with a base, crystallizing and separating the phenol adduct of 2,2-bis(4-hydroxyphenyl) propane from the solution to obtain the purified phenol adduct of 2,2-bis(4-hydroxyphenyl) propane; (E) decomposing the purified phenol adduct of 2,2-bis (4-hydroxyphenyl) propane obtained in the above-mentioned step (D), on heating, to form a thermally decomposed product containing phenol and 2,2-bis(4-hydroxyphenyl) propane; (F) recoverying the phenol and 2,2-bis(4-hydroxyphenyl) propane from the thermally decomposed product obtained in the above-mentioned step (E); and (G) circulating the phenol recovered in the above-mentioned step (F) to the reactor in the above-mentioned step (A) as a circulating phenol or to the above-mentioned step (D) as a phenol solvent.

  一种在含盐酸催化剂存在下通过苯酚和丙酮反应连续生产高质量 2,2-双（4-羟基苯基）丙烷的工艺，包括以下步骤： 1： (A) 通过将额外的苯酚、下述循环苯酚、额外的丙酮、额外的氯化氢或盐酸、下述循环油性母液和下述水性母液连续加入反应器来进行反应，以形成反应混合物浆液，该浆液包括晶体形式的 2，2-双（4-羟基苯基）丙烷的粗苯酚加成物以及油性母液和水性母液两种液相反应母液； (B) 将反应混合物浆液从反应器中排出后，将反应混合物浆液分离成 2,2-双（4-羟基苯基）丙烷的粗酚加合物和两种液相母液； (C) 将上述步骤(B)中得到的两种液相母液分离成油性母液和水性母液，其中油性母液作为循环油性母液循环到反应器中，剩余部分水性母液在排出一部分后作为循环水性母液循环到反应器中； (D) 将上述步骤(B)中得到的 2,2-双(4-羟基苯基)丙烷的粗酚加合物溶解在苯酚溶剂中，用碱中和粗酚加合物中含有的氯化氢或盐酸后，从溶液中结晶分离出 2,2-双(4-羟基苯基)丙烷的酚加合物，得到纯化的 2,2-双(4-羟基苯基)丙烷的酚加合物； (E) 将上述步骤(D)中得到的 2,2-双(4-羟基苯基)丙烷的纯化苯酚加合物加热分解，形成含有苯酚和 2,2-双(4-羟基苯基)丙烷的热分解产物； (F) 从上述步骤(E)得到的热分解产物中回收苯酚和 2,2-双(4-羟基苯基)丙烷；以及 (G) 将上述步骤(F)中回收的苯酚作为循环苯酚循环到上述步骤(A)中的反应器中，或作为苯酚溶剂循环到上述步骤(D)中。
• Optical polycarbonate compositions
  申请人：GE PLASTICS JAPAN LIMITED

  公开号：EP0520806A2

  公开（公告）日：1992-12-30

  An optical polycarbonate composition is obtained by : formulating [B] a boron compound in an amount of 0.00001-0.2 part by weight per 100 parts by weight of [A] a polycarbonate resin having an intrinsic viscosity of 0.30-0.65 dL/g, as measured in 20°C methylene chloride; or by replacing [B] by, or by adding to [A] and [B], an acid compound having a pKa value of 3 or less and/or a derivative formed from said compound in an amount of 0.00001-0.0005 part by weight. The acid compound may be a sulfonic acid compound. Other substances may also be added.

  一种光学聚碳酸酯组合物是通过以下方法获得的：： 配制 每 100 重量份的[A]聚碳酸酯树脂中，[B]硼化合物的用量为 0.00001-0.2 重量份 [A]一种聚碳酸酯树脂，其固有粘度为 0.30-0.65 dL/g（在 20℃二氯甲烷中测得）； 或用 pKa 值为 3 或更小的酸化合物和/或由上述化合物形成的衍生物代替[B]，或向[A]和[B]中加入 0.00001-0.0005 份（重量）的量。 酸化合物可以是磺酸化合物。也可添加其他物质。