2,8-双(苯基甲基)-2,8-二氮杂螺[5.5]十一烷-1,7-二酮 | 128244-02-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2,8-双(苯基甲基)-2,8-二氮杂螺[5.5]十一烷-1,7-二酮
• 英文名称: 2,8-bis(diphenylmethyl)-2,8-diazaspiro<5.5>undecane-1,7-dione
• 英文别名: N,N'-Bisbenzyl-2,8-diazaspiro[5,5]undecane-1,7-dione；2,8-Dibenzyl-2,8-diazaspiro[5.5]undecane-1,7-dione
• CAS: 128244-02-0
• 化学式: C₂₃H₂₆N₂O₂
• 分子量: 362.472
• InChiKey: QALSVTWHUKILFX-UHFFFAOYSA-N

物化性质

• 熔点：
  122-125 °C
• 沸点：
  613.1±55.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,8-双(苯基甲基)-2,8-二氮杂螺[5.5]十一烷-1,7-二酮 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 2,8-bis(diphenylmethyl)-2,8-diazaspiro<5.5>undecane
  参考文献：
  名称：

  Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships

  摘要：

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.

  DOI：

  10.1021/jm00170a035
• 作为产物：
  描述：

  双(2-氰乙基)丙二酸二乙酯 在 镍 氢气 、 sodium hydride 作用下， 以 乙醇 为溶剂， 生成 2,8-双(苯基甲基)-2,8-二氮杂螺[5.5]十一烷-1,7-二酮
  参考文献：
  名称：

  Dispiromacrocycles: A class of diamide and diimide ionophores

  摘要：

  A series of novel ionophores was synthesized in three steps from acrylonitrile and diethyl malonate or malononitrile via 2,8-diazaspiro[5,5]undecane-1,7-dione (7) or 2,8-diazaspiro[5,5]undecane-1,3,7,9-tetrone (8). Spirodiamide macrocycle 14 imparts selectivity for lithium to potentiometric ion-selective electrodes.

  DOI：

  10.1016/s0040-4039(00)77468-5

文献信息

• CULBERTSON, TOWNLEY P.;SANCHEZ, JOSEPH P.;GAMBINO, LAURA;SESNIE, JOSEPHIN+, J. MED. CHEM., 33,(1990) N, C. 2270-2275
  作者：CULBERTSON, TOWNLEY P.、SANCHEZ, JOSEPH P.、GAMBINO, LAURA、SESNIE, JOSEPHIN+

  DOI：——

  日期：——
• US5128466A
  申请人：——

  公开号：US5128466A

  公开（公告）日：1992-07-07
• Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships
  作者：Townley P. Culbertson、Joseph P. Sanchez、Laura Gambino、Josephine A. Sesnie

  DOI：10.1021/jm00170a035

  日期：1990.8

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.
• Dispiromacrocycles: A class of diamide and diimide ionophores
  作者：Thomas W. Bell、Heung-Jin Choi、Gary Hiel

  DOI：10.1016/s0040-4039(00)77468-5

  日期：1993.2

  A series of novel ionophores was synthesized in three steps from acrylonitrile and diethyl malonate or malononitrile via 2,8-diazaspiro[5,5]undecane-1,7-dione (7) or 2,8-diazaspiro[5,5]undecane-1,3,7,9-tetrone (8). Spirodiamide macrocycle 14 imparts selectivity for lithium to potentiometric ion-selective electrodes.