Major urinary metabolites of hexazinone in rats /includes the following/: 3-(4-hydroxycyclohexyl)-6-(dimethylamino)-1-methyl-1,3,5-triazine- 2,4-(1H,3H)-dione (metabolite A); 3-cyclohexyl-6-(methylamino)-1-methyl- 1,3,5-triazine-2,4-(1H,3H)-dione (metabolite B); and 3-(4-hydroxycyclohexyl)-6- (methylamino)-1-methyl-1,3,5-triazine-2,4-(1H,3H)-dione (metabolite C). The percentages of these metabolites detected in the urine were 46.8, 11.5 and 39.3%, respectively. The major fecal metabolites ... were A (26.3%) and C (55.2%). Less than 1% unchanged hexazinone was detected in the urine or the feces.
IDENTIFICATION AND USE: Hexazinone is a white crystalline solid. It is used as an herbicide. HUMAN EXPOSURE AND TOXICITY: A 26-year-old woman inhaled hexazinone dust. Vomiting occurred within 24 hours. ANIMAL STUDIES: In a 10-day study dermal application of hexazinone for 6 hours/day for 10 days to male rabbits at 70 or 680 mg/kg/day resulted in no signs of skin irritation or toxicity. A trend toward elevated serum alkaline phosphatase (SAP) and serum glutamic pyruvic-transaminase (SGPT) activities was observed. Severe ocular irritant in rabbits. Rats fed 5000 ppm had growth curves slightly inferior to those of controls as the only detectable difference. Extending the feeding period to 2 yr produced decreased body weights in males fed 2500 ppm and in females fed either 1000 or 2500 ppm. All other indices of response, including the type and incidence of tumors, were similar in the test and control rats. Mice after 8 wk feeding up to 10,000 ppm produced increased liver weight only at the highest level without any other changes. 2 yr feeding of either 200, 2500, or 10,000 ppm resulted in sloughing of the distal tip of the tail and increased liver weights among mice fed 10,000 ppm. Hypertrophy of centrilobular hepatocytes and hyperplastic nodules were increased in mice fed either 2500 or 10,000 ppm. No evidence of a tumorigenic response was evident. Dogs fed 5000 ppm for 90 days had decreased rate of body weight gain with clinical signs of enzyme changes suggestive of liver damage. Microscopic examination of the liver failed to reveal any alterations and dogs fed 200 or 1000 ppm were indistinguishable from controls. No evidence of a teratogenic effect was seen in either rats or rabbits and reproduction capacity in rats fed up to 2500 ppm for three generations was unaffected. No carcinogenicity was detected among pups of rats fed up to 5000 ppm for 2 years. Similarly, no increase in tumors was produced by feeding up to 10,000 ppm hexazinone to mice. Hexazinone tested negative for mutagenicity in Salmonella typhimurium strains TA 1535, TA 1537, TA 1538, TA 98 and TA 100 at concentrations up to 7,000 ug/plate. ECOTOXICITY STUDIES: Two avian reproduction studies conducted show that the No Observed Effect Concentration (NOEC) for the bobwhite quail is <100 and for the mallard duck is >1000 ppm. Signal crayfish is more sensitive than the fish for hexazinone, and can be used as a bio-indicator of environmental contamination. Hexazinone was tested for its ability to control aquatic weeds when applied at 1.0 ppm in a 0.08 hectare pond. Dissolved oxygen declined from 8.0 ppm to 0.2 ppm within 5 days after treatment and appeared to be the cause of fish mortality observed 4 days post treatment.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌性证据
癌症分类：D组 不可归类为人类致癌性
Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌物分类
对人类不具有致癌性（未被国际癌症研究机构IARC列名）。
No indication of carcinogenicity to humans (not listed by IARC).
来源:Toxin and Toxin Target Database (T3DB)
毒理性
副作用
ACGIH 致癌物 - 未分类。
ACGIH Carcinogen - Not Classifiable.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
口服己唑隆尚未在任何组织中显示出优先积累的现象。/剂量未指定/
Orally administered hexazinone has not been demonstrated to accumulate preferentially in any tissue. /Dose not specified/
... Hexazinone was given in the diet at 0, 1, 5, or 25 ppm to /dairy cows/ for 30 days. ... No detectable residues /were noted/ in milk, fat, liver, kidney or lean muscle.
...Three groups of male and female Sprague Dawley rats were treated as follows: (1) Group A received a single intragastric low dose of (14)C-hexazinone (14 mg/kg) without preconditioning (treatment with non-radioactive hexazinone); (2) Group B received a single intragastric dose of (14)C-hexazinone (14 mg/kg) after three weeks of preconditioning with 100 ppm of non-radioactive hexazinone in the diet; and (3) Group C received a single intragastric high-dose of (14)C-hexazinone (1000 mg/kg) without preconditioning. Hexazinone was rapidly metabolized by hydroxylation and demethylation, and eliminated by the rats in urine and feces during the 3 to 6-day testing periods. About 77% and 20% (of the administered dose) of (14)C-hexazinone was excreted in urine and feces, respectively. Practically all radioactivity was recovered in the first 24 hours after treatment. Very low levels of radioactivity (about 0.2% of the administered dose) were detected in the G.I. tract, hide, organs (heart, lungs, liver, spleen, kidneys, brain, and testes or ovaries), muscle, fat and blood.
/Male rats were/ ... administered 2,500 ppm (125 mg/kg) hexazinone in the diet ... for 17 days. This was followed by a single dose of 18.3 mg/300 g (61 mg/kg) (14)C-labeled hexazinone. The hexazinone was rapidly absorbed within 72 hours, with 61% detected in the urine and 32% in the feces. Trace amounts were found in the gastrointestinal tract (0.6%, tissues not specified) and expired air (0.08%).
[EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
申请人：GILEAD APOLLO LLC
公开号：WO2017075056A1
公开（公告）日：2017-05-04
The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
[EN] 3-[(HYDRAZONO)METHYL]-N-(TETRAZOL-5-YL)-BENZAMIDE AND 3-[(HYDRAZONO)METHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE DERIVATIVES AS HERBICIDES<br/>[FR] DÉRIVÉS DE 3-[(HYDRAZONO))MÉTHYL]-N-(TÉTRAZOL-5-YL)-BENZAMIDE ET DE 3-[(HYDRAZONO)MÉTHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE UTILISÉS EN TANT QU'HERBICIDES
申请人：SYNGENTA CROP PROTECTION AG
公开号：WO2021013969A1
公开（公告）日：2021-01-28
The present invention related to compounds of Formula (I): or an agronomically acceptable salt thereof, wherein Q, R2, R3, R4, R5 and R6 are as described herein. The invention further relates to compositions comprising said compounds, to methods of controlling weeds using said compositions, and to the use of compounds of Formula (I) as a herbicide.
[EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
申请人：SYNGENTA PARTICIPATIONS AG
公开号：WO2013079350A1
公开（公告）日：2013-06-06
Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.
式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
[EN] HERBICIDALLY ACTIVE HETEROARYL-S?BSTIT?TED CYCLIC DIONES OR DERIVATIVES THEREOF<br/>[FR] DIONES CYCLIQUES SUBSTITUÉES PAR HÉTÉROARYLE À ACTIVITÉ HERBICIDE OU DÉRIVÉS DE CELLES-CI
申请人：SYNGENTA LTD
公开号：WO2011012862A1
公开（公告）日：2011-02-03
The invention relates to a compound of formula (I), which is suitable for use as a herbicide wherein G is hydrogen or an agriculturally acceptable metal, sulfonium, ammonium or latentiating group; Q is a unsubstituted or substituted C3-C8 saturated or mono-unsaturated heterocyclyl containing at least one heteroatom selected from O, N and S, or Q is heteroaryl or substituted heteroaryl; m is 1, 2 or 3; and Het is an optionally substituted monocyclic or bicyclic heteroaromatic ring; and wherein the compound is optionally an agronomically acceptable salt thereof.
The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
