dithiocarbonic acid O,S-diphenyl ester | 13509-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dithiocarbonic acid O,S-diphenyl ester
• 英文别名: Dithiokohlensaeure-O,S-diphenylester；Phenylxanthogensaeure-phenylester；diphenyldithiocarbonate；S-Phenyl-O-phenyl-dithiokohlensaeureester；O,S-Diphenyldithiocarbonat；Carbonic acid, dithio-, O,S-diphenyl ester；O-phenyl phenylsulfanylmethanethioate
• CAS: 13509-35-8
• 化学式: C₁₃H₁₀OS₂
• 分子量: 246.354
• InChiKey: GGMYKFODAVNSDF-UHFFFAOYSA-N

物化性质

• 熔点：
  43 °C
• 沸点：
  362.0±15.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.6
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2930902000

反应信息

• 作为反应物：
  描述：

  dithiocarbonic acid O,S-diphenyl ester 在 盐酸 、 sodium nitrite 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 25.0h， 以86%的产率得到O,S-di(phenyl) thiocarbonate
  参考文献：
  名称：

  使用软NO转化⊕ -species

  摘要：

  研究了NaNO 2在酸性溶液中与硫代羰基化合物的反应。仲和叔硫酰胺，1-苄基六氢-2H-氮杂-2-硫酮，5-乙基-5-苯基硫代巴比妥酸，某些硫脲衍生物，2H-1-苯并吡喃-2-硫酮，O，O-二苯基-硫代碳酸酯，O，S-二苯基-二硫代碳酸酯，N，N-二甲基-S-苯基-二硫代氨基甲酸酯，N-乙基-N-苯基-O-乙基-硫代氨基甲酸酯均被转化为相应的羰基类似物。4,4'-双（二甲基氨基）-二苯甲酮（Michler的硫酮）在室温下生成3-硝基-4,​​4'-双（二甲基氨基）-二苯甲酮。在（-10°C）-（-5°C）下，预期的含氧化合物与4-（N-亚硝基-甲基氨基）-4'-（二甲基氨基）-二苯甲酮一起作为主要产物获得。

  DOI：

  10.1016/0040-4020(82)85099-0
• 作为产物：
  描述：

  苯硫酚 在 sodium hydroxide 、 乙醇 、 氯仿 、 水 作用下， 生成 dithiocarbonic acid O,S-diphenyl ester
  参考文献：
  名称：

  Rivier, Bulletin de la Societe Chimique de France, 1907, vol. <4>1, p. 736

  摘要：

  DOI：

文献信息

• Studies of the Thiocarbonyl Compounds. I. Syntheses and Thermal Rearrangement of<i>O</i>,<i>S</i>-Diaryl Dithiocarbonates
  作者：Yoshiaki Araki

  DOI：10.1246/bcsj.43.252

  日期：1970.1

  S-diaryl dithiocarbonates with the general formula of p-X–C6H4–S–C(=S)–O–C6H4–Y-p (I) were prepared. When these substances were kept at an elevated temperature, they rearranged smoothly to S,S-diaryl dithiocarbonates of this general formula: p-X–C6H4–S–C(=O)–S–C6H4-Y-p (II). Kinetic studies showed that the rearrangement followed fairly good first-order kinetics. The rate constants in diphenyl ether at

  制备了通式为 pX–C6H4–S–C(=S)–O–C6H4–Yp (I) 的各种 O,S-二芳基二硫代碳酸酯。当这些物质保持在高温下时，它们会顺利地重排为以下通式的 S,S-二芳基二硫代碳酸酯：pX–C6H4–S–C(=O)–S–C6H4-Yp (II)。动力学研究表明，重排遵循相当好的一级动力学。二苯醚在 200°C 时的速率常数按顺序增加：Y=OCH3
• FIBER COATED NANOPORES
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US20160169864A1

  公开（公告）日：2016-06-16

  Provided herein are compositions, compounds, processes, and methods of use of 3D porous coating(s) on or near a nanopore(s) for analysis or detection of charged polymers such as nucleic acids, proteins, protein-nucleic acid complexes, small molecule-biological complexes, polymer-biological complexes, and/or polyelectrolytes.

  本文提供了关于在或靠近纳米孔上使用3D多孔涂层进行带电高分子（如核酸、蛋白质、蛋白质-核酸复合物、小分子-生物复合物、高分子-生物复合物和/或聚电解质）分析或检测的组合物、化合物、过程和使用方法。
• Cell-Laden Hydrogels
  申请人：Khademhosseini Alireza

  公开号：US20080193536A1

  公开（公告）日：2008-08-14

  The present invention provides cell-laden hydrogels and hydrogel assemblies thereof for use in tissue engineering. The invention provides microscale hydrogels (i.e. microgels) having greatest dimensions ranging between about 1 μm and 1000 μm. The present invention provides methods of producing inventive hydrogels and hydrogel assemblies and pharmaceutical compositions thereof.

  本发明提供了含有细胞的水凝胶及其水凝胶组件，用于组织工程。该发明提供微观水凝胶（即微胶）的最大尺寸范围在约1μm至1000μm之间。本发明提供了生产创新水凝胶和水凝胶组件的方法，以及其制药组合物。
• Student assessment of postgraduate clinical pharmacy programmes in the United Kingdom (1): validation of the course experience questionnaire
  作者：John Quinn、Ian Bates、Roy Cox

  DOI：10.1111/j.2042-7174.2000.tb01012.x

  日期：2011.2.22

  Confirming the validity of the previously published course experience questionnaire (CEQ), a tool in general use in higher education, will enable its specific use in the evaluation of postgraduate clinical pharmacy programmes. The postgraduate clinical pharmacy programmes of interest may have unique aspects to them which may affect validity of the CEQ, for example, the dual emphasis on learning experience through both a formal class environment and workplace practice activities.

  To validate the course experience questionnaire (CEQ), a tool used for student evaluation of higher education provision.

  A UK postal survey, using the CEQ, of graduates from clinical pharmacy postgraduate programmes. Cases were subject to exploratory factor analysis and compared with previous, non-pharmacy samples.

  Graduates from 11 different postgraduate clinical pharmacy programmes in the UK since 1990 were surveyed. A total of 511 questionnaires were distributed and 364 (72 per cent) were returned.

  Factor analysis showed that the sample exhibited similar key constructs to other higher education samples. An important finding was a split in the “good teaching” construct in this postgraduate sample. This split reflects the type of teaching delivery common in postgraduate clinical pharmacy programmes.

  The validation of this important evaluation tool for use in higher education means that comparisons can now be made between institutions and programmes, providing evidence for the quality of provision of these programmes from the student's perspective.

  摘要 背景 确认先前发表的课程体验问卷（CEQ）的有效性，这是高等教育中普遍使用的工具，将使其能够在评估研究生临床药学项目时得到特定应用。感兴趣的研究生临床药学项目可能具有独特的方面，这些方面可能会影响CEQ的有效性，例如，通过正式课堂环境和工作实践活动两者强调学习体验。 目标 验证课程体验问卷（CEQ），这是用于学生评估高等教育提供的工具。 方法 对英国临床药学研究生项目的毕业生进行CEQ的邮寄调查。案例经过探索性因素分析，并与先前的非药学样本进行比较。 设置 自1990年以来，对英国11个不同的临床药学研究生项目的毕业生进行了调查。共发放了511份问卷，364份（72％）已返回。 主要发现 因素分析显示，样本展示了与其他高等教育样本类似的关键构造。一个重要发现是在这个研究生样本中“良好教学”构造的分裂。这种分裂反映了研究生临床药学项目中常见的教学方式。 结论 验证这一重要的高等教育评估工具的使用意味着现在可以对机构和项目进行比较，从学生的角度提供这些项目的质量证据。
• Student assessment of postgraduate clinical pharmacy programmes in the United Kingdom (2): results of the course experience questionnaire
  作者：John Quinn、Ian Bates、Roy Cox

  DOI：10.1111/j.2042-7174.2000.tb01013.x

  日期：2011.2.22

  The principal objective of this paper was to use the course experience questionnaire (CEQ30) instrument to compare and evaluate aspects of provision of postgraduate clinical pharmacy programmes available through institutions of higher education in the United Kingdom.

  A postal survey, using the CEQ, of graduates from clinical pharmacy postgraduate programmes. Cases were subject to factor analysis, comparative statistics and regression analysis to describe differences between aspects of programme provision.

  Graduates from 10 different postgraduate clinical pharmacy programmes in the UK since 1990 were surveyed. A total of 511 questionnaires were distributed and 364 were returned (72 per cent).

  Significant differences between institutions were identified in key factors of student-evaluated aspects of higher education. Factors were generally rated low by respondents. Some programmes appear more likely to encourage surface approaches to learning rather than deep learning. Analysis of factor scores enabled a ranking table to be drawn up for the postgraduate programmes included.

  Evaluation of individual programmes shows differences in rating of aspects of provision. There is scope for postgraduate clinical pharmacy programmes to improve. The study findings raise the question of whether these differences in the learning experience may affect the quality of clinical pharmacy graduate.

  本文的主要目的是使用课程体验问卷（CEQ30）工具，比较和评估英国高等教育机构提供的研究生临床药学课程的各个方面。

  通过邮寄调查CEQ，对临床药学研究生课程的毕业生进行调查。对案例进行因子分析、比较统计和回归分析，以描述课程提供方面的差异。

  调查了自1990年以来英国10个不同的临床药学研究生课程的毕业生。共分发了511份问卷，364份被回收（72%）。

  在学生评估的高等教育方面的关键因素中，发现了机构之间的显著差异。受访者普遍对这些因素的评价较低。一些课程似乎更有可能鼓励表面学习方法而不是深度学习。因子分数的分析使得可以为包括的研究生课程制定排名表。

  对个别课程的评估显示了提供方面评价的差异。有改进研究生临床药学课程的空间。研究结果引发了一个问题，即这些学习经历上的差异是否会影响临床药学研究生的质量。