ethidium iodide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethidium iodide
• 英文别名: 2,7-diamino-10-ethyl-9-phenylphenanthridinium iodide；5-Ethyl-3-imino-6-phenylphenanthridin-8-amine;hydroiodide
• 化学式: C₂₁H₂₀N₃*I
• 分子量: 441.314
• InChiKey: SJPSPCODIPFASV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.14
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  55.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Carbamimidoyl-benzenediazonium 、 ethidium iodide 生成 4-[[(3-Amino-5-ethyl-6-phenylphenanthridin-5-ium-8-yl)amino]diazenyl]benzenecarboximidamide
  参考文献：
  名称：

  Selective Interactions of Ethidiums with G-Quadruplex DNA Revealed by Surface-Enhanced Raman Scattering

  摘要：

  通过表面增强拉曼光谱（SERS）研究了 G-四重构象（G4）寡核苷酸与四种乙啶衍生物之间形成的复合物，以详细了解支持 G4 稳定化的复合物的拓扑结构。溴化乙锭（EB）稳定寡核苷酸 G4 构象的能力较弱，与游离的 EB 相比，与 G4 结合后 SERS 强度没有改变。我们选择了三种乙啶衍生物，因为它们稳定 G4 的能力比 EB 更强。与 G4 形成的寡核苷酸结合后，这三种啶衍生物的 SERS 强度分别下降了约 6、3.5 和 15 倍。SERS 的高淬灭被解释为银胶体对 G4 结合的乙啶失去了可及性。这可能代表了一种新的选择性参数，有助于识别 G4 稳定分子。为了分析寡核苷酸序列对相互作用模式的作用，研究人员与 8 个 G4 形成的寡核苷酸形成了复合物，其中三个环分别为 5'-TTA-3' 或 5'-AAA-3'。乙啶的光谱对与 3' 和 5' G4 端相反的两个侧环都很敏感。这些环的序列被认为在乙啶与 G4 的相互作用模式中具有选择性。

  DOI：

  10.1021/ac034123o

文献信息

• Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment
  申请人：——

  公开号：US20030100615A1

  公开（公告）日：2003-05-29

  Polyamines having the formula: 1 or a salt thereof with a pharmaceutically acceptable acid wherein: R 1 -R 6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chain interrupted by at least one etheric oxygen atom, or hydrogen; N 1 , N 2 , N 3 and N 4 are nitrogen atoms capable of protonation at physiological pH's; a and b may be the same or different and are integers from 1 to 4; A, B and C may be the same or different and are bridging groups which effectively maintain the distance between the nitrogen atoms such that the polyamines: (i) are capable of uptake by a target cell upon administration thereof to a human or non-human animal; and (ii) upon uptake by the target cell, competitively bind via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intracellular natural polyamines in the target cell; the polyamines, upon binding to the biological counter-anion in the cell, function in a manner biologically different than the intracellular polyamines, the polyamines not occurring in nature; as well as pharmaceutical compositions embodying the polyamines and methods of treating patients requiring anti-neoplastic therapy.

  聚胺具有以下化学式：1或其与药用可接受酸盐，其中：R1-R6可能相同或不同，为烷基、芳基、芳基烷基、环烷基，或可由至少一个醚氧原子中断的烷基链组成，或氢；N1、N2、N3和N4是氮原子，在生理pH下能够质子化；a和b可能相同或不同，为1至4的整数；A、B和C可能相同或不同，是有效维持氮原子之间距离的桥联基团，使得聚胺：(i)能够在给予人类或非人类动物后被靶细胞吸收；以及(ii)在被靶细胞吸收后，通过正电荷氮原子之间的静电相互作用与靶细胞内的天然聚胺基本相同地与生物学反离子结合；这些聚胺在细胞内与生物反离子结合后，以生物学上与细胞内聚胺不同的方式发挥作用，这些聚胺在自然界中不存在；以及包含聚胺的药物组合物和治疗需要抗肿瘤治疗的患者的方法。
• [EN] METHODS FOR CELL IMAGING<br/>[FR] PROCÉDÉS D'IMAGERIE CELLULAIRE
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2021119268A1

  公开（公告）日：2021-06-17

  The present application provides a compound of Formula (A), or a pharmaceutically acceptable salt thereof, wherein R1, L1, n, L2, m, L3, p, Y1, Y2, and Y3 are as described herein. Methods of using the compound of Formula (A) to prepare an antibody conjugate, and methods of using these conjugates for cellular imaging are also described.

  本申请提供了一种公式（A）的化合物或其药学上可接受的盐，其中R1、L1、n、L2、m、L3、p、Y1、Y2和Y3的描述如下。还描述了使用公式（A）的化合物制备抗体偶联物的方法，以及使用这些偶联物进行细胞成像的方法。
• Biocompatible carbon based electrode, its use and preparation process
  申请人：Université Pierre et Marie Curie (Paris 6)

  公开号：EP2747158A1

  公开（公告）日：2014-06-25

  An electrode comprising a biocompatible chemically oxygen terminated or H-terminated carbon-based material, the surface of which is substantially free of any peptide coating and promotes the growth or at least the direct interfacing of adult neurons on said material without substantially promoting the growth and direct interfacing of glial cells on said material, said carbon-based material having an electrical conductivity of at least about 0.01S/cm, in particular 1S/cm, said material being in particular selected from the group consisting of nanocrystalline diamond which is doped by either boron, phosphorus or nitrogen, to become a semiconductor, or graphene, nanotubes, or nanotubes on diamond. Further disclosed is a use of said electrode as well as a process of preparation of said electrode.

  一种电极，包括生物相容性化学氧端或 H 端碳基材料，其表面基本上不含任何肽涂层，可促进成体神经元在所述材料上的生长或至少是直接连接，而不会在所述材料上实质性地促进神经胶质细胞的生长和直接连接，所述碳基材料的导电率至少约为 0.01S/cm，尤其是 1S/cm，所述材料尤其选自由掺入硼、磷或氮成为半导体的纳米晶钻石或石墨烯、纳米管或钻石上的纳米管组成的组。 进一步公开了所述电极的用途以及所述电极的制备过程。
• Anti proliferative preparations
  申请人：I.B.R. Israeli Biotechnology Research Ltd.

  公开号：US20020071878A1

  公开（公告）日：2002-06-13

  A dormant preparation (DC) is provided which is capable of inhibiting proliferation of various kinds of cells. The preparation comprises an extract which is obtained from cells or tissue originating in an organism capable of entering a phase of dormancy in at least one of its parts and comprises at least one substance which induces or maintains the state of dormancy in the organism from which the cells or tissue are derived. The DC may be used for a variety of indications including human medicine and cosmetics, plant growth control and food preservation.

  本发明提供了一种休眠制剂（DC），它能够抑制各种细胞的增殖。该制剂包括一种提取物，该提取物取自能够在其至少一个部分进入休眠期的生物体内的细胞或组织，还包括至少一种能够诱导或维持细胞或组织来源生物体的休眠状态的物质。DC 可用于多种用途，包括人类医药和化妆品、植物生长控制和食品保鲜。
• Method for assessment of particles
  申请人：Larsen Dines Rasmus

  公开号：US20060063146A1

  公开（公告）日：2006-03-23

  The invention relates to imaging methods for assessing quality or quantity parameters of particles in a sample, wherein the particles contain less than 10 6 analyte detectable positions. The method comprises 1) mixing the sample with a targeting species capable of binding an analyte position and a labelling agent, 2) arranging the sample in an exposing domain, allowing electromagnetic signals from the sample to pass to the exterior, 3) exposing a representation of said signals onto an array of detection elements, wherein the representation is subject to a linear enlargement, so that the ratio of the image of a linear dimension on the array of detection elements to the original linear dimension in the exposing domain is smaller than 20:1, 4) detecting the representation as intensities by said detection elements, 5) processing the intensities to identify the particles, and 6) obtaining the quality or quantity parameter.

  本发明涉及评估样品中颗粒质量或数量参数的成像方法，其中颗粒的含量小于 10 6 分析检测位置。该方法包括：1）将样品与能够结合分析位置的靶标物质和标记剂混合；2）将样品置于曝光域中，允许来自样品的电磁信号传递到外部；3）在检测元件阵列上曝光所述信号的表示，其中表示受线性放大的影响，以便检测元件阵列上线性尺寸的图像与曝光域中原始线性尺寸的比率小于 20：1，4）通过所述检测元件将表示检测为强度，5）处理强度以识别颗粒，6）获得质量或数量参数。