3-溴-2-苯乙烯基色酮 | 104387-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 3-溴-2-苯乙烯基色酮
• 英文名称: 3-bromo-2-styrylchromone
• 英文别名: 3-Bromo-2-styrylchromone；3-bromo-2-(2-phenylethenyl)chromen-4-one
• CAS: 104387-28-2
• 化学式: C₁₇H₁₁BrO₂
• 分子量: 327.177
• InChiKey: ZOFGJRLNZOTZEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-溴-2-苯乙烯基色酮 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以50%的产率得到2-cinnamoyl-3(2H)-benzofuranone
  参考文献：
  名称：

  Gaggad, H. L.; Wadodkar, K. N.; Ghiya, B. J., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 1244 - 1247

  摘要：

  DOI：
• 作为产物：
  描述：

  2-bromo-1-(2-hydroxyphenyl)-5-phenyl-4-pentene-1,3-dione 在 硫酸 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 以50%的产率得到3-溴-2-苯乙烯基色酮
  参考文献：
  名称：

  Saraf, B. D.; Wadodkar, K. N., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 771 - 772

  摘要：

  DOI：

文献信息

• 2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study
  作者：Clementina M.M. Santos、Marisa Freitas、Daniela Ribeiro、Ana Gomes、Artur M.S. Silva、José A.S. Cavaleiro、Eduarda Fernandes

  DOI：10.1016/j.bmc.2010.07.044

  日期：2010.9

  Xanthones are a class of oxygen-containing heterocyclic compounds widely distributed in nature. The natural derivatives can present different substitutions in the xanthone core that include hydroxyl, methoxyl, prenyl and glycosyl groups. The inclusion of aryl groups has only been reported for a few synthetic derivatives, the 2,3-diaryl moiety being recently introduced by our group. Xanthones are endowed with a broad spectrum of biological activities, many of them related to their antioxidant ability, including the scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal chelating effects. Considering the interesting and promising antioxidant activities present in compounds derived from the xanthone core, the main goal of this work was to evaluate the scavenging activity of the new 2,3-diarylxanthones for ROS, including superoxide radical (O-2(center dot-)), hydrogen peroxide (H2O2), singlet oxygen (O-1(2)), peroxyl radical (ROO center dot) and hypochlorous acid (HOCl), and RNS, including nitric oxide ((NO)-N-center dot) and peroxynitrite anion (ONOO center dot). The obtained results revealed that the tested 2,3-diarylxanthones are endowed with outstanding ROS and RNS scavenging properties, considering the nanomolar to micromolar range of the IC50 values found. The xanthones with two catechol rings were the most potent scavengers of all tested ROS and RNS. In conclusion, the new 2,3-diarylxanthones are promising molecules to be used for their potential antioxidant properties. (C) 2010 Elsevier Ltd. All rights reserved.
• Gaggad, H. L.; Wadodkar, K. N.; Ghiya, B. J., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 1244 - 1247
  作者：Gaggad, H. L.、Wadodkar, K. N.、Ghiya, B. J.

  DOI：——

  日期：——
• Saraf, B. D.; Wadodkar, K. N., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 771 - 772
  作者：Saraf, B. D.、Wadodkar, K. N.

  DOI：——

  日期：——