3-甲氧基-2-丁醇 | 53778-72-6

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-甲氧基-2-丁醇
• 英文名称: 2-methoxy-3-butanol
• 英文别名: 3-methoxy-2-butanol；2.3-butylene glycol-monomethyl ether；2.3-Butylenglykol-monomethylaether；3-methoxybutan-2-ol
• CAS: 53778-72-6
• 化学式: C₅H₁₂O₂
• 分子量: 104.149
• InChiKey: HJHFJCUIVDTESF-UHFFFAOYSA-N

物化性质

• 沸点：
  134-136 °C
• 密度：
  0.9186 g/cm3(Temp: 15 °C)
• 保留指数：
  1903;1910
• 稳定性/保质期：
  存在于主流烟气中。

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2909499000

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3-Methoxy-2-butanol
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 3-Methoxy-2-butanol
CAS number: 53778-72-6

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C5H12O2
Molecular weight: 104.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-甲氧基-2-丁醇 生成 1,3-丁二烯
  参考文献：
  名称：

  Kolfenbach, Iowa State College Journal of Science, 1944, vol. 19, p. 36

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-3-甲氧基-丁烷 在 alkaline solution 作用下， 生成 3-甲氧基-2-丁醇
  参考文献：
  名称：

  Lichoscherstow; Alexejew, Zhurnal Obshchei Khimii, 1934, vol. 4, p. 1281

  摘要：

  DOI：
• 作为试剂：
  描述：

  N-3-[3-(1-哌啶甲基)-苯氧基]丙胺 、 N-(4-乙氧基苯基)氨基甲酸乙酯 以 二氯甲烷 、 3-甲氧基-2-丁醇 为溶剂， 生成 N-(4-Ethoxyphenyl)-N'-[3-(3-piperidinomethylphenoxy)propyl]urea
  参考文献：
  名称：

  Anti-ulcer urea derivatives

  摘要：

  尿素衍生物的化学式如下：##STR1## 其中R.sub.1表示一个哌啶基团或吡咯啉基团，可以被氢氧基或含有1至3个碳原子的较低烷基基团取代；A表示一个乙烯基、丙烯基、丁烯基或丁二烯基；R.sub.2表示一个直链或支链烷基基团，含有1至20个碳原子，环烷基基团，含有3至6个碳原子，苄基或苯基，可能有1至3个取代基，如含有1至6个碳原子的较低烷基基团、含有1至3个碳原子的较低烷氧基团、卤原子、三氟甲基基团、氨基、硝基或亚甲基二氧基基团；X表示一个氧原子或硫原子，其水合物和药学上可接受的酸盐对抗溃疡剂具有用途。

  公开号：

  US04952591A1

文献信息

• [EN] NON-FUSED TRICYCLIC COMPOUNDS<br/>[FR] COMPOSÉS TRICYCLIQUES NON FUSIONNÉS
  申请人：VIVACE THERAPEUTICS INC

  公开号：WO2018204532A1

  公开（公告）日：2018-11-08

  Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

  本文提供了包含所述化合物的化合物和药物组合物，用于治疗癌症。具体的癌症包括那些由YAP/TAZ介导或由YAP/TAZ与TEAD相互作用调节的癌症。
• Novel polymer-supported ruthenium and iron complexes that catalyze the conversion of epoxides into diols or diol mono-ethers: clean and recyclable catalysts
  作者：Sun Hwa Lee、Eun Yong Lee、Dong-Woo Yoo、Sung Jin Hong、Jung Hwan Lee、Han Kwak、Young Min Lee、Jinheung Kim、Cheal Kim、Jin-Kyu Lee

  DOI：10.1039/b707028d

  日期：——

  Polymer-supported metal (Fe or Ru) complexes for epoxide ring opening reactions were successfully prepared by anchoring the bis(2-picolyl)amine ligand onto the polymer poly(chloromethylstyrene-co-divinylbenzene) (PCD); the catalysts showed heterogeneous catalytic activity and easy recyclability in the ring opening reactions of various epoxide substrates with methanol or H2O at room temperature under mild and neutral conditions.

  基于聚合物的金属（Fe或Ru）配合物催化环氧化物开环反应，通过将双(2-吡啶甲基)胺配体锚定到聚合物聚(氯甲基苯乙烯-共-二乙烯基苯)（PCD）上，成功制备而成；这些催化剂在室温下的温和中性条件下，对多种环氧化物底物与甲醇或水的开环反应表现出异相催化活性和易于回收的特性。
• Studies on the Catalytic-Oxidation of Alkanes and Alkenes by Titanium Silicates
  作者：C.B. Khouw、C.B. Dartt、J.A. Labinger、M.E. Davis

  DOI：10.1006/jcat.1994.1285

  日期：1994.9

  thus TS-1 can be used as an oxidation catalyst with aqueous H2O2 as oxidant. Alkyl hydroperoxides are active as oxidants for alkene epoxidation on the TiO2-SiO2 coprecipitate but not for alkane oxidation reactions on both TS-1 and the TiO2-SiO2 coprecipitate. A plausible explanation for the above results is provided. The presence of stereoscrambling without any "radical clock" rearrangement during alkane

  研究了含钛，无铝的ZSM-5（TS-1）和无定形TiO 2 -SiO 2共沉淀物，作为在低于100°C的温度下使用多种氧化剂选择性氧化烷烃和烯烃的催化剂。比较TS-1和TiO 2 -SiO 2共沉淀物使用非水H 2 O 2进行烷烃氧化和烯烃环氧化的活性，表明不存在水对于二氧化硅负载的钛的催化活性至关重要。由于TS-1的疏水性，钛周围的水浓度保持在较低的水平，因此TS-1可用作H 2 O水溶液的氧化催化剂2作为氧化剂。氢过氧化物烷基对于在TiO 2 -SiO 2共沉淀物上的烯烃环氧化具有活性，但对于TS-1和TiO 2 -SiO 2共沉淀物的烷烃氧化反应均无活性。提供了上述结果的合理解释。在TS-1的烷烃氧化过程中，存在没有任何“自由基钟”重排的立体扰动，表明形成的自由基可能具有非常短的寿命，或者它们的运动受到限制，因此不会发生重排。给出了在TS-1上烷烃氧化机理的建议，并将其与在TS-1和TiO
• Petrow, Zhurnal Obshchei Khimii, 1940, vol. 10, p. 981,988
  作者：Petrow

  DOI：——

  日期：——
• Petrow, Zhurnal Obshchei Khimii, 1934, vol. 4, p. 1222
  作者：Petrow

  DOI：——

  日期：——