4,7-二溴异苯并呋喃-1,3-二酮 | 25834-16-6

• 物质功能分类: 化学试剂 - 有机试剂 - 羧酸酐
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 4,7-二溴异苯并呋喃-1,3-二酮
• 中文别名: 3,6-二溴邻苯二甲酸酐
• 英文名称: 3,6-dibromophthalic anhydride
• 英文别名: 4,7-dibromoisobenzofuran-1,3-dione；4,7-dibromo-2-benzofuran-1,3-dione
• CAS: 25834-16-6
• 化学式: C₈H₂Br₂O₃
• 分子量: 305.91
• InChiKey: OUAOHMOFJGFOSR-UHFFFAOYSA-N

物化性质

• 熔点：
  207.0 to 212.0 °C
• 沸点：
  424.8±35.0 °C(Predicted)
• 密度：
  2.267±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 储存条件：
  存放于惰性气体中，并避免接触湿气（以免发生分解）。

反应信息

• 作为反应物：
  描述：

  4,7-二溴异苯并呋喃-1,3-二酮 在 吡啶 、 盐酸羟胺 作用下， 反应 5.0h， 以99%的产率得到N-hydroxy-3,6-dibromophthalimide
  参考文献：
  名称：

  四芳基取代的并五苯的光化学合成

  摘要：

  通过相应的α-二酮前体的光脱羰作用描述了1,4,8,11-四苯基并五苯和1,4,8,11-四（2'-噻吩基）并五苯的合成。

  DOI：

  10.1016/j.tetlet.2010.01.009
• 作为产物：
  描述：

  苯酐 在 fuming sulphuric acid 、 溴 、 碘 作用下， 生成 4,7-二溴异苯并呋喃-1,3-二酮
  参考文献：
  名称：

  高性能有机薄膜晶体管和反相器通过构象变化来优化基于噻吩乙烯撑的聚合物半导体的双极性电荷传输

  摘要：

  我们报道了作为薄膜晶体管中高效双极性半导体的基于亚噻吩乙烯撑的供体-受体交替共聚物（PTVPhI-Eh和PTVPhI-C12）的合成和表征。这些聚合物在热退火后表现出明显改善的空穴和电子迁移率。为了确定双极性电荷传输和热退火之间的关系，我们使用各种分析方法研究了这些聚合物，例如光学光谱，拉曼光谱，计算量子化学计算，X射线衍射，原子力显微镜和双极性电荷迁移率测量。在原始膜中，聚合物链表现出较弱的链内和链间有序性。但是，当样品在足够高的温度下退火时，它们表现出更有序的链内和链间构象。结果，我们发现在热退火过程中，聚合物的链内和链间构象变化与相应的双极性电荷传输性质之间存在很强的关系。最后，我们演示了使用PTVPhI-Eh聚合物的互补型双极性逆变器。热退火的逆变器改善了大幅度漂移的逆变电压，该逆变器显示出大的电压增益（约40）。

  DOI：

  10.1021/cm303908f

文献信息

• [EN] SULFONE DERIVATIVES AND THEIR USE AS PKM2 MODULATORS FOR THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS DE SULFONE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE PKM2 POUR LE TRAITEMENT DU CANCER
  申请人：LUPIN LTD

  公开号：WO2013005157A1

  公开（公告）日：2013-01-10

  Provided herein is novel compound of the general formula (I), its tautomeric forms, its stereoisomers, its analogs, its prodrugs, its isotopes, its N- oxides, its metabolites, its pharmaceutically acceptable salts, its polymorphs, its solvates, its optical isomers, its clathrates, its co-crystals, its combinations with suitable medicament and pharmaceutical compositions comprising the same. Also provided is method of treating a disease responsive to activation of human PKM2 by administration of said compound and its use as PKM2 modulator in various pathological conditions.

  提供了一种通用公式（I）的新型化合物，其互变异构体，立体异构体，类似物，前药，同位素，N-氧化物，代谢物，药用可接受盐，多态性，溶剂化物，光学异构体，包合物，共晶，与适宜药物的组合以及包含同一的药物组合物。还提供了一种通过施用所述化合物来治疗对人类PKM2激活有反应的疾病的方法，以及将其用作各种病理条件下的PKM2调节剂。
• [EN] AN ELECTRON-DONATING UNIT, A COPOLYMER THEREOF AND THEIR PREPARATION METHODS, AS WELL AS THEIR USES<br/>[FR] MOTIF DONNEUR D'ÉLECTRONS, SON COPOLYMÈRE ET LEURS PROCÉDÉS DE PRÉPARATION, AINSI QUE LEURS UTILISATIONS
  申请人：UNIV SOUTH SCIENCE & TECHNOLOGY CHINA

  公开号：WO2017152354A1

  公开（公告）日：2017-09-14

  An electron-donating unit of the Formula, a copolymer thereof and their preparation methods, as well as their uses in thin-film transistor or polymer solar cell. The electron-donating unit is an effective building block for constructing high-performance polymer semiconductors due to its solubilizing ability, centrosymmetric geometry, backbone planarity, compact packing, and appropriate electron donating ability versus the previously reported BTOR and DTP units.

  该公式的电子给体单元，其共聚物及其制备方法，以及它们在薄膜晶体管或聚合物太阳能电池中的用途。 由于其溶解能力、中心对称几何形状、主链平面性、紧凑堆积以及适当的电子给体能力，电子给体单元是构建高性能聚合物半导体的有效构建模块，相对于先前报道的BTOR和DTP单元。
• Effect of polymer chain conformation on field-effect transistor performance: synthesis and properties of two arylene imide based D–A copolymers
  作者：Dugang Chen、Yan Zhao、Cheng Zhong、Siqi Gao、Gui Yu、Yunqi Liu、Jingui Qin

  DOI：10.1039/c2jm31755a

  日期：——

  Two donor–acceptor (D–A) alternating copolymers (P1 and P2) with phthalimide or thieno[3,4-c]pyrrole-4,6-dione as the electron acceptor and bithiophene as the electron donor have been synthesized by Stille polycondensation. Both polymers showed good thermal stability and a low HOMO level. Organic field-effect transistor (OFET) devices with common architectures were fabricated to evaluate and compare the FET properties of the two polymers. Though P2 exhibits better coplanarity than P1, the FET results revealed that both the hole mobility and current on–off ratio of P1 are more than one order of magnitude higher than P2. Theoretical calculations and AFM were conducted to analyze the reason for this very interesting result, and it was found that polymer chain conformation is another important factor (in addition to coplanarity) for polymers to obtain high FET performance.

  通过Stille缩聚反应合成了两种具有酞菁或噻吩[3,4-c]吡咯-4,6-二酮作为电子受体，双噻吩作为电子供体的供体-受体（D-A）交替共聚物（P1和P2）。这两种聚合物均表现出良好的热稳定性和较低的HOMO能级。制备了具有常见结构的OFET器件，以评估和比较这两种聚合物的FET性能。尽管P2比P1具有更好的共面性，但FET结果显示P1的空穴迁移率和电流开-关比P2高出不止一个数量级。进行了理论计算和AFM分析，以探讨这一非常有趣的结果的原因，并发现聚合物链构象是聚合物获得高FET性能的另一个重要因素（除共面性之外）。
• Organic bulk heterojunction solar cells based on solution processable small molecules (A–π–A) featuring 2-(4-nitrophenyl) acrylonitrile acceptors and phthalimide-based π-linkers
  作者：G. D. Sharma、J. A. Mikroyannidis、Rajnish Kurchania、K. R. Justin Thomas

  DOI：10.1039/c2jm16915k

  日期：——

  A novel small molecule-based organic donor SM [(2Z,2′Z)-3,3′-(((1E,1′E)-(2-cyclohexyl-1,3-dioxoisoindoline-4,7-diyl)bis(ethene-2,1-diyl))bis(4,1-phenylene))bis(2-(4-nitrophenyl)-acrylonitrile)] featuring 2-(4-nitrophenyl)acrylonitrile as the acceptor and a π-conjugation bridge composed of phthalimide and styryl units, with an A–π–A type structure, has been synthesized. It showed a long wavelength absorption band having an absorption maximum around 635 nm and the optical bandgap was 1.63 eV, which is lower than most reported conjugated polymers, including poly(3-hexylthiophene) (P3HT). The photovoltaic properties were investigated by constructing bulk heterojunction organic solar cell devices using SM as the electron donor and fullerene derivatives, i.e. PC60BM and PC70BM as the electron acceptors with the device architecture ITO/PEDOT:PSS/SM:PC60BM or PC70BM/Al. The effect of the SM/fullerene derivative weight ratio and the processing solvent were carefully investigated to improve the performance of the organic solar cells. The optimized organic solar cell with SM:PC60BM and SM:PC70BM cast from THF solvent, at a weight ratio of 1 : 3 showed power conversion efficiencies (PCEs) of about 1.70% and 2.56%, respectively. The enhanced value of PCE for the BHJ photovoltaic device based on PC70BM is related to the better absorption of PC70BM in the visible region compared to that of PC60BM. The SM:PC70BM blends cast from a DIO–THF mixture and subsequent thermal annealing exhibited improved PCEs of 3.68% and 4.14%, respectively.

  一种新型小分子有机供体SM [(2Z，2'Z)-3，3'((1E，1'E)-(2-环己基-1，3-二氧异吲哚啉-4，7-二基)双(亚乙基-2，1-二基))双(4，1-苯ylene))双（2-(4-硝基苯基)-丙烯腈)]已经合成，其中2-(4-硝基苯基)丙烯腈作为受体，phthalimide和styryl单元组成的π-共轭桥接，结构类型为A-π-A型。它显示出一个长波长吸收带，吸收最大值约为635纳米，光学带隙为1.63电子伏特，这比大多数报道的共轭聚合物要小，包括聚(3-己基噻吩)(P3HT)。通过使用SM作为电子供体，富勒烯衍生物，即PC60BM和PC70BM作为电子受体，构建了体异质结有机太阳能电池器件，其结构为ITO/PEDOT：PSS/SM：PC60BM或PC70BM/Al。仔细研究了SM/富勒烯衍生物重量比和处理溶剂对提高有机太阳能电池性能的影响。最佳的有机太阳能电池以THF溶剂铸造的SM：PC60BM和SM：PC70BM，在重量比为1：3时，功率转换效率(PCEs)分别为约1.70%和2.56%。基于PC70BM的BHJ光伏器件的PCE增强值与PC70BM在可见区域比PC60BM更好的吸收有关。从DIO-THF混合物铸造的SM：PC70BM混合物，并在随后进行了热退火，显示出了改善的PCEs分别为3.68%和4.14%。
• Semiconducting Compounds and Devices Incorporating Same
  申请人：Watson Mark D.

  公开号：US20100252112A1

  公开（公告）日：2010-10-07

  Disclosed are semiconducting compounds having one or more phthalimide units and/or one or more head-to-head (H-H) substituted biheteroaryl units. Such compounds can be monomeric, oligomeric, or polymeric, and can exhibit desirable electronic properties and possess processing advantages including solution-processability and/or good stability at ambient conditions.

  本文披露了具有一个或多个邻苯二酰亚胺单元和/或一个或多个头-头（H-H）取代的双杂环芳基单元的半导体化合物。这些化合物可以是单体、寡聚体或聚合物，可以表现出理想的电子性能，并具有处理优势，包括可溶性处理和/或在常温条件下良好的稳定性。