硫化钴 | 1317-42-6

• 物质功能分类: 无机化工 - 无机盐 - 金属硫化物及硫酸盐
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属有机体
• 中文名称: 硫化钴
• 中文别名: 一硫化钴；硫化钴(II)
• 英文名称: cobalt sulfide
• 英文别名: cobalt monosulfide；sulfanylidenecobalt
• CAS: 1317-42-6
• 化学式: CoS
• 分子量: 91.0592
• InChiKey: VRRFSFYSLSPWQY-UHFFFAOYSA-N

物化性质

• 熔点：
  >1116°C
• 密度：
  5,45 g/cm3
• 溶解度：
  不溶于水；溶于酸溶液
• 暴露限值：
  a/nm
• 物理描述：
  OtherSolid; PelletsLargeCrystals
• 颜色/状态：
  Black amorphous powder
• 稳定性/保质期：
  如果按照规格使用和储存，则不会分解，没有已知危险反应。应避免接触氧化物和酸。 钴有α-CoS和β-CoS两种形态：α-CoS为黑色无定形粉末，在空气中会氧化变为Co(OH)S；β-CoS则为灰色或带红色的结晶，与NiAs晶型相同，难溶于水但可溶于酸。

计算性质

• 辛醇/水分配系数(LogP)：
  0.65
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.1
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

代谢

钴通过肺部、胃肠系统和皮肤被吸收。由于它是维生素B12（氰钴胺）的一个组成部分，因此它被分布到身体的大多数组织中。它在血液中运输，通常与白蛋白结合，肝脏和肾脏中的含量最高。钴主要通过尿液和粪便排出。

Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

识别和使用：硫化钴是一种黑色无定形粉末。它用作氢化或加氢脱硫的催化剂。人类暴露和毒性：硫化钴刺激人类多形核白细胞（PMNs）产生H2O2。动物研究：单次肌内注射硫化钴使大鼠的横纹肌肉瘤发生率为50%，但小鼠不会。在含有氧化钴和硫化钴的工业精炼尘埃的给药六个月后，小鼠诱发了纤维肉瘤。在大鼠处理的钴、其合金或分别用氧化钴或硫化钴的粉末中观察到注射部位肉瘤。将CHO细胞暴露于结晶硫化钴10微克/毫升24小时后诱导DNA链断裂。

IDENTIFICATION AND USE: Cobalt monosulfide is black amorphous powder. It is used as a catalyst for hydrogenation or hydrodesulfurization. HUMAN EXPOSURE AND TOXICITY: Cobalt monosulfide stimulated human polymorphonuclear leukocytes (PMNs) to produce H2O2. ANIMAL STUDIES: Single im injection of cobalt sulfide gave a 50% incidence of rhabdomyosarcoma in rats but not in mice. Fibrosarcomas were induced in mice 6 months after the parenteral injection of an industrial refining dust containing cobalt oxide and cobalt sulfide. Injection site sarcoma was observed in rats treated with powder of cobalt, its alloys, or with cobalt oxide or cobalt sulfide, respectively. Exposure of CHO cells to crystalline cobalt sulfide at 10 ug/mL for 24 hr induced DNA strand breaks.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

钴被认为通过氧化剂和自由基过程表现出其毒性。它产生氧自由基，并可能被氧化成离子态的钴，导致脂质过氧化增加、DNA损伤，并诱导某些酶，导致细胞凋亡。钴还被证明可以阻断无机钙通道，可能损害神经传递。钴还可以与硫辛酸螯合，损害丙酮酸或脂肪酸的氧化。此外，钴可能通过与锌指DNA修复蛋白相互作用来抑制DNA修复，并且已被证明可以抑制血红素合成和葡萄糖代谢。钴可能激活特定的辅助性T淋巴细胞，并直接与免疫蛋白（如抗体IgA和IgE或Fc受体）相互作用，导致免疫致敏。

Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (L29)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌性证据

... 对于硫化钴(II)在实验动物中的致癌性，只有有限的证据。 ... 总体评估：钴和钴化合物可能对人类有致癌性（2B组）。 /钴和钴化合物/

... There is limited evidence for the carcinogenicity of cobalt(II) sulfide in experimental animals. ... Overall Evaluation: Cobalt and cobalt compounds are possibly carcinogenic to humans (Group 2B). /Cobalt and cobalt compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

钴和钴化合物在人类中的致癌性证据不足。有充分的证据表明钴金属粉末在实验动物中具有致癌性。有限证据表明含有钴、铬和钼的金属合金在实验动物中具有致癌性。...总体评估：钴和钴化合物可能对人类具有致癌性（2B组）。/钴和钴化合物/

There is inadequate evidence for the carcinogenicity of cobalt and cobalt compounds in humans. There is sufficient evidence for the carcinogenicity of cobalt metal powder in experimental animals. There is limited evidence for the carcinogenicity of metal alloys containing cobalt, chromium and molybdenum in experimental animals. ... Overall Evaluation: Cobalt and cobalt compounds are possibly carcinogenic to humans (Group 2B). /Cobalt and cobalt compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A3：已确认的动物致癌物，对人类的相关性未知。/钴和钴的无机化合物/

A3: Confirmed animal carcinogen with unknown relevance to humans. /Cobalt and inorganic compounds, as Co/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• TSCA：
  Yes
• 危险等级：
  9
• 危险品标志：
  Xi,N
• 安全说明：
  S24,S37,S60,S61
• 危险类别码：
  R43
• 危险品运输编号：
  UN 3077
• RTECS号：
  GG3325000
• 海关编码：
  2830903000
• 危险类别：
  9

SDS

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Section 1: Product Identification
Chemical Name: Cobalt (II) sulfide (99.5%-Co)
CAS Registry Number: 1317-42-6
Formula: CoS
EINECS Number: 215-273-3
Chemical Family: metal chalcogenides
Synonym: Cobalt monosulfide, Cobaltous sulfide

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 1317-42-6 100% 0.02mg/m3 (as Co) no data

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Section 3: Hazards Identification
Irritating to eyes, skin and respiratory tract. May cause sensitization by skin contact. Limited evidence of a
Emergency Overview:
carcinogenic effect. Possible risk of irreversible effects.
Primary Routes of Exposure: Ingestion, inhalation, skin and eyes
Eye Contact: Causes mild to moderate irritation of the eyes.
Skin Contact: Causes slight irritation of the skin. may cause sensitization by skin contact.
Inhalation: Irritating to the nose, mucous membranes and respiratory tract.Hydrogen sulfide gas, if formed, is poisonous.
May cause abdominal pain, nausea, vomiting, flushing of the face and ears, mild hypotension, rash and
Ingestion:
ringing in the ears.
Irritating to eyes, skin and respiratory tract. Hydrogen sulfide gas may cause painful conjunctivitis, headache,
Acute Health Affects:
nausea, dizziness, pulmonary edema and possible death.
Repeated oral administration may produce goiter and reduced thyroid activity. Prolonged or repeated skin
Chronic Health Affects: exposure may cause dermatitis. Chronic exposure associated with kidney, heart and lung damage. Limited
evidence of a carcinogenic effect. Possible risk of irreversible effects.
NTP: No
IARC: Yes
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point: not applicable
Autoignition Temperature: no data
Explosion Limits: no data
Extinguishing Medium: carbon dioxide or dry powder
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self- contained breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material may emit irritating fumes of hydrogen sulfide and sulfur dioxide.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
Spill and Leak Procedures: Small spills can be mixed with vermiculite or sodium carbonate and swept up.

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SECTION 7: Handling and Storage
Store in a tightly sealed container. Exposure to the atmosphere may lead to release of toxic hydrogen sulfide
Handling and Storage:
gas. Empty containers may retain product residues that evolve toxic gases.

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SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear appropriate chemical resistant gloves and protective clothing.
Ventilation: If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of a respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: If possible, handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: -200 mesh black pwdr.
Molecular Weight: 91
Melting Point: no data
Boiling Point: no data
Vapor Pressure: no data
Specific Gravity: 5.45
Odor: none
Solubility in Water: Insoluble

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SECTION 10: Stability and Reactivity
Stability: moisture sensitive
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: Reaction with mineral acids can lead to formation of toxic fumes of hydrogen sulfide.
Incompatibility: Mineral acids, active metals and oxidizing agents
Decomposition Products: hydrogen sulfide, sulfur dioxide, and metal oxides.

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SECTION 11: Toxicological Information
Oral (rat); LD50: >5 gm/kg. Intramuscular (rat); TDLo: 180 mg/kg. Hamster embryo; Morphological
RTECS Data: transfusion: 1 mg/L. Hamster ovary; DNA damage: 10 mg/L. Hamster lung; Mutation in mammalian somatic
cells: 25 mg/m3.
Carcinogenic Effects: Possible carcinogen (as Co)
Mutagenic Effects: Possible mutagen
Tetratogenic Effects: no data

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SECTION 12: Ecological Information
Ecological Information: Harmful to aquatic organisms. May cause long-term adverse effects in the aquatic environment.

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SECTION 13: Disposal Considerations
This material and its container must be disposed of as hazardous waste according to local, state and federal
Disposal:
regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Non-hazardous
Hazard Class (CFR): NA
Additional Hazard Class (CFR): NA
Packaging Group (CFR): NA
UN ID Number (CFR): NA
Shipping Name (IATA): Non-hazardous
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): NA

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SECTION 15: Regulatory Information
TSCA: Listed in the TSCA inventory.
SARA (Title 313): Title compound: see category code N096 for reporting.
Second Ingredient: none

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

概述

一硫化钴的化学式为CoS，分子量91.00。它以两种形式存在：α-型黑色不定形粉末，在空气中会转变成Co(OH)S，并且易溶于盐酸；β-型则呈现灰色粉末或银红色八面体晶体形态，熔点高于1116℃，相对密度为5.45。此化合物微溶于酸中而不溶于水。

制备方法包括：在隔绝空气的条件下，向硝酸钴水溶液通入硫化氢生成沉淀物；将该沉淀物缓缓升温至106～500℃进行干燥，即可得到β-型一硫化钴。另一种制备方式是在真空环境下将金属钴粉与硫磺封入石英管中，并于700℃加热72小时后获得α-型。

用途

一硫化钴微溶于酸且不溶于水，可作为催化剂或用于制备化工原料，例如制备一种硫掺杂的磷化钴/碳纳米纤维复合材料。

用途

用于提取钴原料。

类别

有毒物质

毒性分级

低毒

急性毒性

口服-大鼠 LD50: > 5000 毫克/公斤

可燃性危险特性

不可燃烧；火场会产生含有钴化物和硫氧化物的烟雾

储运特性

应存放在通风、低温干燥的库房中

灭火剂

二氧化碳、砂土、水

反应信息

• 作为反应物：
  描述：

  硫化钴 生成 氧化钴
  参考文献：
  名称：

  ASAKI Z.; NITTA M.; TANABE T.; KONDO Y., MET. TRANS., 17,(1986) N 1-4, 367-373

  摘要：

  DOI：
• 作为产物：
  描述：

  cobalt selenite 生成 硫化钴
  参考文献：
  名称：

  ZHUMASHEV, K.;MULDAGALIEVA, R. A., 10 BCEC. SOVESHCH. PO TERM. ANAL., LENINGRAD, CEHT., 1989, L.,(1989) S. 3+

  摘要：

  DOI：
• 作为试剂：
  描述：

  allyl 3-nitrobenzoate 、 在 硫化钴 氢气 、 碳酸氢钠 、 甲醇 作用下， 以 甲醇 为溶剂， 反应 2.17h， 以gives 366 g of 3-aminobenzoic acid allyl ester的产率得到3-氨基-苯甲酸烯丙酯
  参考文献：
  名称：

  Process for the preparation of unsaturated amino compounds

  摘要：

  一种制备还含有C-C多重键的芳香胺的方法，其特点在于在存在钴硫化物催化剂的情况下，将还含有C-C多重键的芳香硝基化合物在20°C至140°C和5至150巴氢气压下加氢。

  公开号：

  US04051177A1

文献信息

• Bulusheva, N. E.; Fioletova, T. N.; Krichevskii, G. E., Journal of applied chemistry of the USSR, 1988, vol. 61, p. 1878 - 1881
  作者：Bulusheva, N. E.、Fioletova, T. N.、Krichevskii, G. E.、Zakhar'in, D. S.、Reiman, S. I.

  DOI：——

  日期：——
• VITT, B., PROC. SOC. PHOTO-OPT. INSTRUM. ENG., 823,(1987) C. 218-224
  作者：VITT, B.

  DOI：——

  日期：——
• ORLOVSKAYA, L. V., TR. AN LITSSR. B,(1989) N, S. 39-45
  作者：ORLOVSKAYA, L. V.

  DOI：——

  日期：——
• TAKAHASHI, YASUHITO;SAKAI, SHILGERU;INOUE, YOSHIMASA
  作者：TAKAHASHI, YASUHITO、SAKAI, SHILGERU、INOUE, YOSHIMASA

  DOI：——

  日期：——
• KALYUZHNYJ, A. V.;SESYUNINA, E. A., 3 REGION. SOVESHCH. RESP. SRED. AZII I KAZAXSTANA PO XIM. REAKTIVAM, 16-1+
  作者：KALYUZHNYJ, A. V.、SESYUNINA, E. A.

  DOI：——

  日期：——