ethyl 7-hydroxy-3-methyl-4-azahept-2-enoate | 134896-23-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 7-hydroxy-3-methyl-4-azahept-2-enoate
• 英文别名: β-<(3-Hydroxypropyl)amino>crotonsaeure-ethylester；β-[(3-Hydroxypropyl)amino]crotonsaeure-ethylester；ethyl (Z)-3-(3-hydroxypropylamino)but-2-enoate
• CAS: 134896-23-4
• 化学式: C₉H₁₇NO₃
• 分子量: 187.239
• InChiKey: QERGZOBSCXSDQU-FPLPWBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-ethyl 2-benzylidenacetoacetate 、 ethyl 7-hydroxy-3-methyl-4-azahept-2-enoate 以 乙醇 为溶剂， 以53%的产率得到diethyl 3-hydroxy-5-((3-hydroxypropyl)amino)-3-methyl-1,2,3,4-tetrahydro-[1,1'-biphenyl]-2,6-dicarboxylate
  参考文献：
  名称：

  Synthesis of substituted 5-N-(R)amino-4-cyclohexyl-1-ols by the reaction of secondary enaminones of β-dicarbonyl compounds with chalcones

  摘要：

  Reaction of secondary enaminones of acetylacetone or acetoacetic ester with chalcones at room temperature, is shown to lead to 5-N-(R)amino-4-cyclohexen-1-ols, distinctly to the reaction of the related primary derivatives leading to 1,4-dihydropyridines. Tertiary enaminones of identical structure are found not reacting with chalcones under the similar conditions. The reasons for the difference in the behavior of primary, secondary and tertiary enaminones in the reaction with chalcones are discussed.

  DOI：

  10.1134/s1070363211100203
• 作为产物：
  描述：

  乙酰乙酸乙酯 、 3-氨基-1-丙醇 以93%的产率得到ethyl 7-hydroxy-3-methyl-4-azahept-2-enoate
  参考文献：
  名称：

  Vainiotalo, Pirjo; Savolainen, Pirjo-Liisa; Ahlgren, Markku, Journal of the Chemical Society. Perkin transactions II, 1991, # 5, p. 735 - 741

  摘要：

  DOI：

文献信息

• Synthesis of substituted 5-N-(R)amino-4-cyclohexyl-1-ols by the reaction of secondary enaminones of β-dicarbonyl compounds with chalcones
  作者：M. S. Sargsyan、S. S. Hayotsyan、A. Kh. Khachatryan、A. E. Badasyan、S. G. Kon’kova

  DOI：10.1134/s1070363211100203

  日期：2011.10

  Reaction of secondary enaminones of acetylacetone or acetoacetic ester with chalcones at room temperature, is shown to lead to 5-N-(R)amino-4-cyclohexen-1-ols, distinctly to the reaction of the related primary derivatives leading to 1,4-dihydropyridines. Tertiary enaminones of identical structure are found not reacting with chalcones under the similar conditions. The reasons for the difference in the behavior of primary, secondary and tertiary enaminones in the reaction with chalcones are discussed.
• Vainiotalo, Pirjo; Savolainen, Pirjo-Liisa; Ahlgren, Markku, Journal of the Chemical Society. Perkin transactions II, 1991, # 5, p. 735 - 741
  作者：Vainiotalo, Pirjo、Savolainen, Pirjo-Liisa、Ahlgren, Markku、Maelkoenen, Pentti J.、Vepsaelaeinen, Jouko

  DOI：——

  日期：——