N-tert-butoxycarbonyl-6-(2'-nitrophenyl)caprolactam | 264231-49-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-tert-butoxycarbonyl-6-(2'-nitrophenyl)caprolactam
• 英文别名: Tert-butyl 2-(2-nitrophenyl)-7-oxoazepane-1-carboxylate；tert-butyl 2-(2-nitrophenyl)-7-oxoazepane-1-carboxylate
• CAS: 264231-49-4
• 化学式: C₁₇H₂₂N₂O₅
• 分子量: 334.372
• InChiKey: YDGRHABHCPCBOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  92.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-tert-butoxycarbonyl-6-(2'-nitrophenyl)caprolactam 在 lithium hydroxide 、 水 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 4.0h， 生成 6-(2'-nitrophenyl)-6-(N-tert-butoxycarbonyl)amino caproic acid methyl ester
  参考文献：
  名称：

  Two Useful Photolabile Surfaces for Solid-Phase Synthesis

  摘要：

  o-Nitrobenzyl-based photolabile surfaces 3 and 4 have been synthesized from 2-phenylcyclohexanone and aminopropylsiloxane-grafted controlled pore glass. The procedures are simple and inexpensive and generate materials whose minimally functionalized reactive chromophore should tolerate a range of subsequent chemistries, Time- and solvent-dependent analysis of photodegradation demonstrates a performance comparable to related photolabile systems.

  DOI：

  10.1021/ol0056224
• 作为产物：
  描述：

  2-苯基环己酮 在 4-二甲氨基吡啶 、 sodium azide 、 nitronium tetrafluoborate 、 硫酸 作用下， 以 四氢呋喃 、 硝基甲烷 为溶剂， 反应 4.83h， 生成 N-tert-butoxycarbonyl-6-(2'-nitrophenyl)caprolactam
  参考文献：
  名称：

  Two Useful Photolabile Surfaces for Solid-Phase Synthesis

  摘要：

  o-Nitrobenzyl-based photolabile surfaces 3 and 4 have been synthesized from 2-phenylcyclohexanone and aminopropylsiloxane-grafted controlled pore glass. The procedures are simple and inexpensive and generate materials whose minimally functionalized reactive chromophore should tolerate a range of subsequent chemistries, Time- and solvent-dependent analysis of photodegradation demonstrates a performance comparable to related photolabile systems.

  DOI：

  10.1021/ol0056224

文献信息

• Two Useful Photolabile Surfaces for Solid-Phase Synthesis
  作者：Troy D. Ryba、Patrick G. Harran

  DOI：10.1021/ol0056224

  日期：2000.3.1

  o-Nitrobenzyl-based photolabile surfaces 3 and 4 have been synthesized from 2-phenylcyclohexanone and aminopropylsiloxane-grafted controlled pore glass. The procedures are simple and inexpensive and generate materials whose minimally functionalized reactive chromophore should tolerate a range of subsequent chemistries, Time- and solvent-dependent analysis of photodegradation demonstrates a performance comparable to related photolabile systems.