4-甲氧基-6-甲基喹啉 | 99842-59-8

• 物质功能分类: 医药中间体 - 杂环化合物 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-甲氧基-6-甲基喹啉
• 英文名称: 4-methoxy-6-methyl-quinoline
• 英文别名: 4-Methoxy-6-methyl-chinolin；4-Methoxy-6-methylchinolin；4-Methoxy-6-methylquinoline
• CAS: 99842-59-8
• 化学式: C₁₁H₁₁NO
• mdl: MFCD03729743
• 分子量: 173.214
• InChiKey: DTKDECMXVFQCGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  4-甲氧基-6-甲基喹啉 、 碘甲烷 在 苯 作用下， 生成 4-methoxy-1,6-dimethyl-quinolinium; iodide
  参考文献：
  名称：

  Profft et al., Wissenschaftliche Zeitschrift der Technischen Hochschule Carl Schorlemmer Leuna-Merseburg, 1959, vol. 2, p. 93,97

  摘要：

  DOI：
• 作为产物：
  描述：

  1-benzoyl-6-methyl-1,2-dihydro-quinoline-2-carbonitrile 在 sodium hydroxide 、 溴 、 sodium carbonate 作用下， 以 甲醇 为溶剂， 反应 9.0h， 生成 4-甲氧基-6-甲基喹啉
  参考文献：
  名称：

  Synthesis of 4-Alkoxyquinolines from Quinoline Reissert Compounds

  摘要：

  The quinoline Reissert compound (5a) was converted to 1-benzoyl-3-bromo-2-cyano-1, 2, 3, 4-tetrahydro-4-methoxyquinoline (6a) by successive treatment in methanol with bromine and aq. sodium carbonate. Hydrolysis of 6a with hydrochrolic acid gave 3-bromoquinoline (4; R = H), but that with aq. sodium hydroxide afforded 4-methoxyquinoline (7a). Reissert compounds derived from some quinoline derivatives (5) gave the corresponding 4-methoxyquinolines (7) through tetrahydroquinolines (6) in a similar way.

  DOI：

  10.3987/com-91-5945

文献信息

• [EN] AKT3 MODULATORS<br/>[FR] MODULATEURS DE AKT3
  申请人：GEORGIAMUNE LLC

  公开号：WO2021226458A1

  公开（公告）日：2021-11-11

  Compounds of Formula la, lb, or Ic, (Ia); (Ib); or (Ic), are described, where the various substituents are defined herein. The compounds can modulate a property or effect of Akt3 in vitro or in vivo, and can also be used, individually or in combination with other agents, in the prevention or treatment of a variety of conditions. Methods for synthesizing the compounds are described. Pharmaceutical compositions and methods of using these compounds or compositions, individually or in combination with other agents or compositions, in the prevention or treatment of a variety of conditions are also described.

  本文描述了化合物la、lb或Ic的公式(Ia)；(Ib)；或(Ic)，其中各种取代基在此处定义。这些化合物可以在体外或体内调节Akt3的性质或效果，并且还可以单独或与其他药剂结合在预防或治疗各种疾病方面使用。描述了合成这些化合物的方法。还描述了药物组合物和使用这些化合物或组合物的方法，单独或与其他药剂或组合物结合在预防或治疗各种疾病方面。
• Clemo; Perkin, Journal of the Chemical Society, 1925, vol. 127, p. 2303
  作者：Clemo、Perkin

  DOI：——

  日期：——
• Heterocyclic carboxylic acid amides as PDK1 inihibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2560967B1

  公开（公告）日：2017-12-20
• [EN] HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'ANTAGONISTES DE L'ADÉNOSINE
  申请人：NUVATION BIO INC

  公开号：WO2020150674A1

  公开（公告）日：2020-07-23

  Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.
• Synthesis of 4-Alkoxyquinolines from Quinoline Reissert Compounds
  作者：Michiharu Sugiura、Yoshie Sakurai、Yoshiki Hamada

  DOI：10.3987/com-91-5945

  日期：——

  The quinoline Reissert compound (5a) was converted to 1-benzoyl-3-bromo-2-cyano-1, 2, 3, 4-tetrahydro-4-methoxyquinoline (6a) by successive treatment in methanol with bromine and aq. sodium carbonate. Hydrolysis of 6a with hydrochrolic acid gave 3-bromoquinoline (4; R = H), but that with aq. sodium hydroxide afforded 4-methoxyquinoline (7a). Reissert compounds derived from some quinoline derivatives (5) gave the corresponding 4-methoxyquinolines (7) through tetrahydroquinolines (6) in a similar way.