2-chlorocarbonylpentanoyl chloride | 55459-44-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-chlorocarbonylpentanoyl chloride
• 英文别名: n-Propyl-malonylchlorid；Propylmalonsaeure-dichlorid；propyl-malonyl chloride；2-Propylpropanedioyl dichloride
• CAS: 55459-44-4
• 化学式: C₆H₈Cl₂O₂
• 分子量: 183.034
• InChiKey: MLNSYGKGQFHSNI-UHFFFAOYSA-N

物化性质

• 沸点：
  80 °C(Press: 22 Torr)
• 密度：
  1.262±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chlorocarbonylpentanoyl chloride 在 吡啶 、 sodium hydroxide 、 氯仿 作用下， 生成 4,4'-(3,5-dioxo-4-propyl-pyrazolidine-1,2-diyl)-di-benzoic acid
  参考文献：
  名称：

  4-烷基-3：5-二氧杂-1：2-二苯基吡唑烷衍生物

  摘要：

  DOI：

  10.1039/jr9550003158
• 作为产物：
  描述：

  丙基丙二酸 在 氯化亚砜 作用下， 生成 2-chlorocarbonylpentanoyl chloride
  参考文献：
  名称：

  261. 3：5-二氧并吡唑烷的衍生物可能具有治疗活性

  摘要：

  DOI：

  10.1039/jr9590001315

文献信息

• Iromycins:  A New Family of Pyridone Metabolites from <i>Streptomyces</i> sp. II. Convergent Total Synthesis
  作者：Heydar Shojaei、Zhen Li-Böhmer、Paultheo von Zezschwitz

  DOI：10.1021/jo070327j

  日期：2007.7.1

  The total synthesis of iromycin A (1a), a microbial metabolite combining a novel structure with an interesting biological activity as a NO synthase inhibitor, was accomplished using a flexible and highly convergent approach. Thus, the ring fragment was prepared as 6-bromomethylpyrone 27 by acylation of the respective β-ketoester 13 and subsequent lactonization of the thus-obtained β,δ-diketoester 11

  伊洛霉素A（1a）是一种微生物代谢产物，具有新颖的结构和作为NO合酶抑制剂的有趣生物活性，可以通过灵活且高度收敛的方法完成总合成。因此，通过将各自的β-酮酸酯13酰化并且随后将如此获得的β，δ-二酮酸酯11内酯化，然后将6-甲基溴化，将环片段制备为6-溴甲基吡喃酮27。另外，有效地制备了不饱和侧链作为末端炔烃34，然后将其碳铝化以提供烯基二甲基烷烃35。。使用镍，钯和铜催化剂对这两个片段的组装进行了彻底的研究，但仅在形成相应的烯基三烷基丙氨酸锂之后，在没有任何过渡金属的情况下才成功。然后用液氨处理偶联产物41，完成了总合成，在最长线性序列的九个步骤中，总产率为18％。
• METHOD FOR MANUFACTURING COMPOSITE SEMIPERMEABLE MEMBRANE
  申请人：Nitto Denko Corporation

  公开号：EP2489426A1

  公开（公告）日：2012-08-22

  The purpose of the present invention is to provide a method for producing a composite semipermeable membrane, which has excellent chemical resistance, and in which floating of a skin layer is not easily generated. A method for producing a composite semipermeable membrane, of the present invention, characterized in that an atmospheric pressure plasma treatment is performed to a front surface on which a skin layer of an epoxy resin porous support is to be formed, thereafter the skin layer is formed own the front surface.

  本发明的目的是提供一种生产复合半透膜的方法，这种膜具有优异的耐化学性，而且不容易产生表皮层上浮。本发明的一种生产复合半透膜的方法，其特征在于：对环氧树脂多孔支架的表皮层的正面进行常压等离子处理，然后在正面形成表皮层。
• METHOD FOR PRODUCING POROUS THERMOSETTING RESIN SHEET AND COMPOSITE SEPARATION MEMBRANE USING SAME
  申请人：Nitto Denko Corporation

  公开号：EP2589620A1

  公开（公告）日：2013-05-08

  In the step of extracting and removing a porogen from a thermosetting resin sheet 1 containing the porogen, the porogen is extracted and removed by bringing the thermosetting resin sheet 1 into contact with a first liquid that has a relatively low temperature, and subsequently bringing the thermosetting resin sheet 1 into contact with a second liquid that has a relatively high temperature. Preferably, the temperatures of the first liquid and the second liquid are lower than or equal to the glass-transition temperature of the thermosetting resin sheet 1.

  在从含有多孔剂的热固性树脂片 1 中提取和去除多孔剂的步骤中，通过使热固性树脂片 1 与温度相对较低的第一种液体接触，然后使热固性树脂片 1 与温度相对较高的第二种液体接触，来提取和去除多孔剂。第一种液体和第二种液体的温度最好低于或等于热固性树脂板 1 的玻璃化转变温度。
• EPOXY RESIN POROUS MEMBRANE, SEPARATOR FOR NONAQUEOUS ELECTROLYTE STORAGE DEVICE, NONAQUEOUS ELECTROLYTE STORAGE DEVICE, COMPOSITE SEMIPERMEABLE MEMBRANE, AND PROCESS FOR PRODUCING THE SAME
  申请人：Nitto Denko Corporation

  公开号：EP2720293A1

  公开（公告）日：2014-04-16

  The present invention provides a method for producing a porous membrane. The method allows: avoidance of use of a solvent that places a large load on the environment; relatively easy control of parameters such as the porosity and the pore diameter; and high chemical stability of a resultant porous membrane. The method for producing a porous membrane of the present invention includes the steps of: preparing an epoxy resin composition containing an epoxy resin, a curing agent represented by H2N-(CH2)n-NH2 where n is an integer from 4 to 8, and a porogen; forming a cured product of the epoxy resin composition into a sheet shape or curing a sheet-shaped formed body of the epoxy resin composition, so as to obtain an epoxy resin sheet; and removing the porogen from the epoxy resin sheet by means of a halogen-free solvent.

  本发明提供了一种生产多孔膜的方法。该方法可以：避免使用对环境造成较大负荷的溶剂；相对容易地控制孔隙率和孔径等参数；所制得的多孔膜具有较高的化学稳定性。本发明生产多孔膜的方法包括以下步骤：制备环氧树脂组合物，其中包含环氧树脂、以 H2N-(CH2)n-NH2 表示的固化剂（其中 n 为 4 至 8 的整数）和致孔剂；将环氧树脂组合物的固化产物制成片状或固化环氧树脂组合物的片状成型体，从而获得环氧树脂片；以及通过无卤溶剂去除环氧树脂片上的致孔剂。
• METHOD FOR PRODUCING A SEPARATOR FOR A NONAQUEOUS ELECTROLYTE POWER STORAGE DEVICE AND METHOD FOR PRODUCING EPOXY RESIN POROUS MEMBRANE
  申请人：Nitto Denko Corporation

  公开号：EP2854198A1

  公开（公告）日：2015-04-01

  Provided is a method for producing a separator for nonaqueous electrolyte electricity storage devices that includes a porous epoxy resin membrane, the method including: a step (i) of preparing an epoxy resin composition containing an epoxy resin, a curing agent, and a porogen; a step (ii) of cutting a cured product of the epoxy resin composition into a sheet shape or curing a sheet-shaped formed body of the epoxy resin composition so as to obtain an epoxy resin sheet; a step (iii) of removing the porogen from the epoxy resin sheet using a halogen-free solvent so as to form a porous epoxy resin membrane; a step (iv) of irradiating the porous epoxy resin membrane with infrared ray so as to measure infrared absorption characteristics of the porous epoxy resin membrane; and a step (v) of calculating a membrane thickness and/or an average pore diameter of the porous epoxy resin membrane based on the infrared absorption characteristics. This production method can avoid the use of a solvent that places a large load on the environment, and is adapted for control of parameters such as the average pore diameter and the membrane thickness.

  本发明提供了一种用于生产非水电解质储电装置隔膜的方法，该隔膜包括多孔环氧树脂膜，该方法包括步骤(i)制备含有环氧树脂、固化剂和致孔剂的环氧树脂组合物；步骤(ii)将环氧树脂组合物的固化产物切割成片状或固化环氧树脂组合物的片状成型体，以获得环氧树脂片；步骤(iii)使用无卤溶剂从环氧树脂片中去除致孔剂，以形成多孔环氧树脂膜；步骤(iv)用红外线照射多孔环氧树脂膜，以测量多孔环氧树脂膜的红外线吸收特性；以及步骤(v)根据红外线吸收特性计算多孔环氧树脂膜的膜厚和/或平均孔径。这种生产方法可以避免使用对环境造成较大负荷的溶剂，并适用于控制平均孔径和膜厚度等参数。