N-(6-aminohexyl) retinoic amide | 1262863-42-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N-(6-aminohexyl) retinoic amide
• 英文别名: (2e,4e,6e,8e)-N-(6-aminohexyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide；(2E,4E,6E,8E)-N-(6-aminohexyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide
• CAS: 1262863-42-2
• 化学式: C₂₆H₄₂N₂O
• 分子量: 398.632
• InChiKey: JLIZAOGFAANWLQ-CICHKUIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  维A酸 在 4-二甲氨基吡啶 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 6.25h， 生成 N-(6-aminohexyl) retinoic amide
  参考文献：
  名称：

  TRACEABLE RETINOID ACID FOR IMAGING, DISEASE PREVENTION AND THERAPY

  摘要：

  本发明提供了基于视黄酸衍生物结构的非放射性近红外光学成像剂。该非放射性近红外光学成像剂已通过共聚焦显微镜在细胞水平上进行评估，并在整个动物体内利用各种异种移植模型进行评估。该成像剂在人类癌细胞和多个异种移植模型中的特异摄取表明，非放射性近红外染料标记的视黄酸代谢物和/或类似物对于早期癌症研究和诊断是有用的。此外，本发明还提供，非放射性近红外染料标记的视黄酸代谢物和/或类似物对于可视化药物在体内重新分配是有用的，这有助于确定最佳生物剂量。最终，可视化数据可用作分析工具，以减少任何全身毒性。

  公开号：

  US20120244079A1

文献信息

• 약물이 충전된 히알루론산 가교물 하이드로겔 및 이의 이용
  申请人：POSTECH Research and Business Development Foundation 포항공과대학교 산학협력단(220040433361) BRN ▼506-82-07303

  公开号：KR20170010651A

  公开（公告）日：2017-02-01

  본 발명은 약물을 담지한 생체적합성 히알루론산 가교물 하이드로겔, 이를 포함하는 조성물, 및 이의 제조 방법에 관한 것으로 하이드로겔에서의 약물 방출을 통해 질병을 치료할 수 있다.

  本发明涉及含有药物的生物相容性透明质酸交联物水凝胶，包括该组合物，以及其制备方法，通过水凝胶中药物的释放可以治疗疾病。
• [EN] TRACEABLE RETINOID ACID FOR IMAGING, DISEASE PREVENTION AND THERAPY<br/>[FR] ACIDE RÉTINOÏQUE TRAÇABLE POUR IMAGERIE, PRÉVENTION DE LA MALADIE ET THÉRAPIE
  申请人：BAYLOR COLLEGE MEDICINE

  公开号：WO2011011105A2

  公开（公告）日：2011-01-27

  The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.
• TRACEABLE RETINOID ACID FOR IMAGING, DISEASE PREVENTION AND THERAPY
  申请人：Ke Shi

  公开号：US20120244079A1

  公开（公告）日：2012-09-27

  The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.

  本发明提供了基于视黄酸衍生物结构的非放射性近红外光学成像剂。该非放射性近红外光学成像剂已通过共聚焦显微镜在细胞水平上进行评估，并在整个动物体内利用各种异种移植模型进行评估。该成像剂在人类癌细胞和多个异种移植模型中的特异摄取表明，非放射性近红外染料标记的视黄酸代谢物和/或类似物对于早期癌症研究和诊断是有用的。此外，本发明还提供，非放射性近红外染料标记的视黄酸代谢物和/或类似物对于可视化药物在体内重新分配是有用的，这有助于确定最佳生物剂量。最终，可视化数据可用作分析工具，以减少任何全身毒性。