dimethyl 5-(2-(2-hydroxyethoxy)ethoxy)benzene-1,3-dicarboxylic acid | 1262102-10-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl 5-(2-(2-hydroxyethoxy)ethoxy)benzene-1,3-dicarboxylic acid
• 英文别名: 5-[2-(2-Hydroxy-ethoxy)-ethoxy]-isophthalic acid dimethyl ester；dimethyl 5-[2-(2-hydroxyethoxy)ethoxy]benzene-1,3-dicarboxylate
• CAS: 1262102-10-2
• 化学式: C₁₄H₁₈O₇
• 分子量: 298.293
• InChiKey: AJUQXEOFPAYNCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  dimethyl 5-(2-(2-hydroxyethoxy)ethoxy)benzene-1,3-dicarboxylic acid 在 水 、 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以97%的产率得到5-(2-(2-hydroxyethoxy)ethoxy)benzene-1,3-dicarboxylic acid
  参考文献：
  名称：

  Comparative solvolytic stabilities of copper(II) nanoballs and dinuclear Cu(II) paddle wheel units

  摘要：

  The self-assembly of copper(II) ions and 5-(2-(2-hydroxyethoxy)ethoxy) benzene-1,3-dicarboxylic acid (2) leads to hollow nanoballs in which 12 dinuclear copper(II) paddle wheel units are interconnected via 24 ligands, as determined by single crystal X-ray structure analysis. The nanoball dissociates in aqueous solutions, and in the presence of an excess of ligand it transforms into a three-dimensional network, but is stable in organic solvents. The thermodynamic stability of the nanoball against dissociation in aqueous solution is studied and compared to simple copper(II) paddle wheel complexes. The results reveal enhanced thermodynamic stability of the nanoball as compared to discrete copper(II) paddle wheel complexes due to chelate effects and positive cooperativity. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.06.022
• 作为产物：
  描述：

  5-羟基间苯二甲酸二甲酯 、 2-氯乙氧基乙醇 在 potassium carbonate 、 potassium iodide 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以79%的产率得到dimethyl 5-(2-(2-hydroxyethoxy)ethoxy)benzene-1,3-dicarboxylic acid
  参考文献：
  名称：

  Comparative solvolytic stabilities of copper(II) nanoballs and dinuclear Cu(II) paddle wheel units

  摘要：

  The self-assembly of copper(II) ions and 5-(2-(2-hydroxyethoxy)ethoxy) benzene-1,3-dicarboxylic acid (2) leads to hollow nanoballs in which 12 dinuclear copper(II) paddle wheel units are interconnected via 24 ligands, as determined by single crystal X-ray structure analysis. The nanoball dissociates in aqueous solutions, and in the presence of an excess of ligand it transforms into a three-dimensional network, but is stable in organic solvents. The thermodynamic stability of the nanoball against dissociation in aqueous solution is studied and compared to simple copper(II) paddle wheel complexes. The results reveal enhanced thermodynamic stability of the nanoball as compared to discrete copper(II) paddle wheel complexes due to chelate effects and positive cooperativity. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.06.022

文献信息

• FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND
  申请人：Lokhov Sergey

  公开号：US20080293586A1

  公开（公告）日：2008-11-27

  Minor groove binder-oligonucleotide probes are provided along with methods for their use wherein the probes have an attached fluorophore which, in an unhybridized form exhibits very low background signal.

  提供了微小沟结合剂寡核苷酸探针以及其使用方法，其中探针具有附加的荧光物质，未杂交形式的荧光物质信号非常低。
• HYPERTHEROMOSTABLE ENDONUCLEASE IV SUBSTRATE PROBE
  申请人：Belousov Yevgeniy

  公开号：US20110151457A1

  公开（公告）日：2011-06-23

  The present invention relates to a hyperthermostable endonuclease IV substrate probe to be used in nucleic acid assay methods which can be carried out using hyperthermostable enzymes, including detection of target nucleic acids, and detection of nucleic acid polymorphism.

  本发明涉及一种高温稳定的内切酶IV底物探针，用于核酸检测方法，该方法可以使用高温稳定酶进行，包括检测目标核酸和检测核酸多态性。
• HYPERTHERMOSTABLE ENDONUCLEASE IV SUBSTRATE PROBE
  申请人：Belousov Yevgeniy

  公开号：US20130022976A1

  公开（公告）日：2013-01-24

  The present invention relates to a hyperthermostable endonuclease IV substrate probe to be used in nucleic acid assay methods which can be carried out using hyperthermostable enzymes, including detection of target nucleic acids, and detection of nucleic acid polymorphism.

  本发明涉及一种高温稳定的内切酶IV底物探针，用于核酸检测方法中，可以使用高温稳定酶进行检测目标核酸和检测核酸多态性。
• US7381818B2
  申请人：——

  公开号：US7381818B2

  公开（公告）日：2008-06-03
• US7759126B2
  申请人：——

  公开号：US7759126B2

  公开（公告）日：2010-07-20