1,3-di-tert-butyl-2-lithio-1,1,3,3-tetramethyltrisilane | 262612-03-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1,3-di-tert-butyl-2-lithio-1,1,3,3-tetramethyltrisilane
• CAS: 262612-03-3
• 化学式: C₁₂H₃₁LiSi₃
• 分子量: 266.576
• InChiKey: AZEDZDBYYTTZSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.05
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,3-di-tert-butyl-2-lithio-1,1,3,3-tetramethyltrisilane 在 1,3-二溴-5,5-二甲基海因 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  α-Sila-二肽：合成与表征

  摘要：

  头两个α-sila-二肽7和环-sila-二肽8是通过几种方法合成并表征的，包括X射线晶体学。庞大的t- BuMe 2 Si取代基为合成分子提供了一定的动力学稳定性。图7和8是氨基酸或肽中心α-位的“ C开关用Si”的第一个例子，其中硅同时与氨基和羰基键合。

  DOI：

  10.1002/anie.201807027
• 作为产物：
  描述：

  1,3-di-tert-butyl-1,1,3,3-tetramethyl trisilane 在 叔丁基锂 作用下， 以 四氢呋喃 、 正戊烷 为溶剂， 反应 1.0h， 以53%的产率得到1,3-di-tert-butyl-2-lithio-1,1,3,3-tetramethyltrisilane
  参考文献：
  名称：

  Sila-metalation Route to Hydrido(trialkylsilyl)silyllithiums

  摘要：

  The proton abstraction (sila-metalation) of trialkylsilyl-substituted dihydridosilanes with t-BuLi or LDA in THF was found to be a convenient route to the corresponding silyllithiums (RR'SiHLi; 1a, R, R' = t-BuMe(2)Si; 1b, R, R' = Me(3)Si; 1c, R, R' = i-Pr(2)MeSi; 1d, R = t-BuMe(2)Si, R' = 4-methylphenyl). Hydridosilylithium 1a was isolated as air- and moisture-sensitive, but thermally stable, colorless crystals. X-ray analysis has shown that 1a is dimeric in the solid state, where two lithium atoms bridge between anionic silicon atoms forming a parallelogram, each lithium atom is coordinated by one THF molecule, and the Si-H hydrogen atoms are in the plane of the parallelogram. X-ray analysis has shown that (t-BuMe(2)Si)(2)GeHLi (5) has a dimeric structure similar to that of 1a.

  DOI：

  10.1021/ja026705d

文献信息

• Sila-metalation Route to Hydrido(trialkylsilyl)silyllithiums
  作者：Takeaki Iwamoto、Junichiro Okita、Chizuko Kabuto、Mitsuo Kira

  DOI：10.1021/ja026705d

  日期：2002.10.1

  The proton abstraction (sila-metalation) of trialkylsilyl-substituted dihydridosilanes with t-BuLi or LDA in THF was found to be a convenient route to the corresponding silyllithiums (RR'SiHLi; 1a, R, R' = t-BuMe(2)Si; 1b, R, R' = Me(3)Si; 1c, R, R' = i-Pr(2)MeSi; 1d, R = t-BuMe(2)Si, R' = 4-methylphenyl). Hydridosilylithium 1a was isolated as air- and moisture-sensitive, but thermally stable, colorless crystals. X-ray analysis has shown that 1a is dimeric in the solid state, where two lithium atoms bridge between anionic silicon atoms forming a parallelogram, each lithium atom is coordinated by one THF molecule, and the Si-H hydrogen atoms are in the plane of the parallelogram. X-ray analysis has shown that (t-BuMe(2)Si)(2)GeHLi (5) has a dimeric structure similar to that of 1a.
• α‐Sila‐Dipeptides: Synthesis and Characterization
  作者：Boris Minkovich、Ilya Ruderfer、Alexander Kaushansky、Dmitry Bravo‐Zhivotovskii、Yitzhak Apeloig

  DOI：10.1002/anie.201807027

  日期：2018.10

  The first two α‐sila‐dipeptides, 7 and cyclo‐sila‐dipeptide 8, were synthesized and characterized by several methods, including X‐ray crystallography. Bulky t‐BuMe2Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a “Si for C switch” in the central α‐position of an amino acid or a peptide, in which silicon is bonded to both the amino

  头两个α-sila-二肽7和环-sila-二肽8是通过几种方法合成并表征的，包括X射线晶体学。庞大的t- BuMe 2 Si取代基为合成分子提供了一定的动力学稳定性。图7和8是氨基酸或肽中心α-位的“ C开关用Si”的第一个例子，其中硅同时与氨基和羰基键合。