Phallacidin | 26645-35-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Phallacidin
• 英文别名: 2-[28-(2,3-dihydroxy-2-methylpropyl)-18-hydroxy-23-methyl-15,21,24,26,29,32,35-heptaoxo-31-propan-2-yl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraen-34-yl]-2-hydroxyacetic acid
• CAS: 26645-35-2
• 化学式: C₃₇H₅₀N₈O₁₃S
• 分子量: 846.9
• InChiKey: KUBDTFZQCYLLGC-UHFFFAOYSA-N

物化性质

• 密度：
  1.1678 (rough estimate)
• 溶解度：
  DMF：可溶； DMSO：可溶；甲醇：可溶；水溶性

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  59
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  354
• 氢给体数：
  12
• 氢受体数：
  14

安全信息

• 危险等级：
  6.1(a)
• 危险品标志：
  T+
• 危险类别码：
  R26/27/28
• 危险类别：
  6.1(a)

制备方法与用途

生物活性方面，Phallacidin 属于鬼笔毒素家族的一种蘑菇毒素，能够结合 F-肌动蛋白。

文献信息

• Identification And Use Of Genes Encoding Amatoxin And Phallotoxin
  申请人：Hallen Heather E.

  公开号：US20100267019A1

  公开（公告）日：2010-10-21

  The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptide toxins and toxin production in mushrooms. In particular, the present invention relates to using genes and proteins from Amanita species encoding Amanita peptides, specifically relating to amatoxins and phallotoxins. In a preferred embodiment, the present invention also relates to methods for detecting Amanita peptide toxin genes for identifying Amanita peptide-producing mushrooms and for diagnosing suspected cases of mushroom poisoning. Further, the present inventions relate to providing kits for diagnosing and monitoring suspected cases of mushroom poisoning in patients.
• Use Of Galerina Marginata Genes And Proteins For Peptide Production
  申请人：Hallen-Adams Heather E.

  公开号：US20120276588A1

  公开（公告）日：2012-11-01

  The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.
• USE OF GALERINA MARGINATA GENES AND PROTEINS FOR PEPTIDE PRODUCTION
  申请人：Board of Trustees of Michigan State University

  公开号：US20160281075A1

  公开（公告）日：2016-09-29

  The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.
• US9273100B2
  申请人：——

  公开号：US9273100B2

  公开（公告）日：2016-03-01
• US9518097B2
  申请人：——

  公开号：US9518097B2

  公开（公告）日：2016-12-13