7,8-氨基壬酸 | 21738-21-6

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 其他氨基酸衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 7,8-氨基壬酸
• 中文别名: 7,8 -氨基壬酸
• 英文名称: 7,8-Diaminononanoic acid
• CAS: 21738-21-6
• 化学式: C₉H₂₀N₂O₂
• mdl: MFCD09842543
• 分子量: 188.27
• InChiKey: KCEGBPIYGIWCDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  链霉素 、 、 7,8-氨基壬酸 、 卡那霉素碱 在 M 作用下， 以 乙酸乙酯 为溶剂， 反应 50.0h， 以to obtain the V12 strain的产率得到L-赖氨酸
  参考文献：
  名称：

  Method for production of L-lysine using methanol-utilizing bacterium

  摘要：

  提供一种生产L-赖氨酸的方法，包括以下步骤：在培养基中培养利用甲醇的细菌，以在培养基中产生和积累L-赖氨酸，并从培养基中收集L-赖氨酸。其中，利用甲醇的细菌包含编码对L-赖氨酸反馈抑制不敏感的双氢二氢吡啶酸合成酶的DNA和编码能够增强L-赖氨酸从利用甲醇的细菌排泄的LysE蛋白的DNA，并且该细菌被改造以增加二氨基戊二酸脱氢酶、二氨基戊二酸脱羧酶、双氢二氢吡啶酸还原酶和天冬氨酸半醛脱氢酶的细胞内活性。

  公开号：

  US08017363B2

文献信息

• [EN] BIOLOGICAL FERMENTATION USING DIHYDROXYACETONE AS A SOURCE OF CARBON<br/>[FR] FERMENTATION BIOLOGIQUE UTILISANT DE LA DIHYDROXYACÉTONE COMME SOURCE DE CARBONE
  申请人：KEMBIOTIX LLC

  公开号：WO2017139420A1

  公开（公告）日：2017-08-17

  The present invention relates to the use of hydrocarbons derived from natural gas in the fermentative production of biochemicals including biofuels. More specifically, the present invention provides the method for manufacturing dihydroxyacetone ("DHA") from natural gas, biogas, biomass and CO2 released from industrial plants including electricity-generating plants, steel mills and cement factories and the use of DHA as a source of organic carbon in the fermentative production of biochemicals including biofuels. The present invention comprises three stages. In the first stage of the present invention, syngas and formaldehyde are produced from natural gas, biogas, biomass and CO2 released from industrial plants. In the second stage of the present invention, formaldehyde and syngas are condensed to produce DHA. In the third stage of the present invention, biochemicals including biofuels are produced from DHA using fermentation process involving wild type or genetically modified microbial biocatalysts.

  本发明涉及使用从天然气中提取的碳氢化合物在生物化学品，包括生物燃料的发酵生产中的应用。更具体地说，本发明提供了一种从天然气、沼气、生物质和工业厂房中释放的CO2中制造二羟基丙酮（"DHA"）的方法，以及将DHA作为有机碳源在发酵生产中制造生物化学品，包括生物燃料的应用。本发明包括三个阶段。在本发明的第一阶段中，从天然气、沼气、生物质和工业厂房中释放的CO2中产生合成气和甲醛。在本发明的第二阶段中，甲醛和合成气被凝结成DHA。在本发明的第三阶段中，使用野生型或基因改造的微生物生物催化剂进行发酵过程，从DHA中生产生物化学品，包括生物燃料。
• Methods for indentifying compounds that modulate an enzyme in the coenzyme a biosynthetic pathway in a pathogenic microoganism
  申请人：Schechter M. Alan

  公开号：US20060094075A1

  公开（公告）日：2006-05-04

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

  一种通过抑制代谢途径中一个或多个酶的活性，抑制底物转化为产生次终产物或终产物的过程，特别是通过抑制途径中一个或多个酶的活性，来识别和治疗病原微生物感染的方法，以及用于抑制这些酶而抑制病原微生物感染的化合物和药物组合物。
• Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway
  申请人：Pyro Pharmaceuticals, Inc.

  公开号：US20030180830A1

  公开（公告）日：2003-09-25

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway

  一种通过抑制代谢途径中一个或多个酶的活性，从而抑制底物转化产生次终产物或最终产物，特别是通过抑制代谢途径中一个或多个酶的活性来识别和治疗病原微生物感染的方法。
• Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway and compounds and pharmaceutical compositions useful therefor
  申请人：Pyro Pharmaceuticals, Inc.

  公开号：US20040006040A1

  公开（公告）日：2004-01-08

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

  一种通过抑制代谢途径中的一个或多个酶，抑制底物转化为产生次终产物或终产物的方法，特别是通过抑制途径中一个或多个酶的活性，用于鉴定和治疗病原微生物感染，以及用于抑制这些酶的化合物和制药组合物，用于抑制病原微生物感染。
• Methods for indentifying compounds that modulate an enzyme involved in reductive carboxylation in a pathogenic microorganism
  申请人：Schechter M. Alan

  公开号：US20060178321A1

  公开（公告）日：2006-08-10

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

  一种通过抑制代谢途径中的一个或多个酶来抑制底物转化为产生次终产物或终产物的方法，特别是通过抑制途径中一个或多个酶的活性，用于鉴定和治疗病原微生物感染，以及用于抑制这些酶的化合物和制药组合物以抑制病原微生物感染的方法。