苯乙基-丙基醚 | 67002-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯乙基-丙基醚
• 英文名称: (2-propoxyethyl)benzene
• 英文别名: phenethyl-propyl ether；Propyl-β-phenaethyl-aether；Phenaethyl-propyl-aether；6-Phenyl-4-oxa-hexan；2-Propoxyethylbenzene
• CAS: 67002-62-4
• 化学式: C₁₁H₁₆O
• 分子量: 164.247
• InChiKey: BEFZWLXEZRSXAY-UHFFFAOYSA-N

物化性质

• 沸点：
  128 °C(Press: 2 Torr)
• 密度：
  1.0078 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  phenyl-acetaldehyde dipropylacetal 在 氢气 、 镍 作用下， 生成 苯乙基-丙基醚
  参考文献：
  名称：

  Sigmund; Marchart, Monatshefte fur Chemie, 1927, vol. 48, p. 279

  摘要：

  DOI：

文献信息

• Tetra-hydroxy-calix[4]arene derivatives with two P(III) or P(V) units attached at the upper rim
  作者：Laure Monnereau、David Sémeril、Dominique Matt、Loïc Toupet

  DOI：10.1016/j.poly.2012.11.040

  日期：2013.3

  bis-(phosphine sulfide) (4) have been synthesized. A single crystal X-ray diffraction study was carried out for bis(phosphine oxide) 3, which revealed a pinched cone conformation for the calixarene core. In the solid state, each calixarene is linked to two other calixarenes via hydrogen bonds involving the phosphoryl groups as well as two of the four hydroxyl groups, thereby generating a supramolecular polymeric

  摘要5,17-双（二苯基膦基）-25,26,27,28-四羟基杯[4]芳烃（2）和相应的双-（氧化膦）（3）和双-（膦硫化物）（ 4）已经合成。对双（氧化膦）3进行了单晶X射线衍射研究，结果显示了杯芳烃核的收缩锥构象。在固态下，每个杯芳烃通过涉及磷酰基以及四个羟基中的两个的氢键与另外两个杯芳烃连接，从而产生超分子聚合物结构。由二膦2选择性地形成螯合复合物失败，可能是由于苯氧基的快速跨环旋转阻止了适当的配体预组织。与适当的Ru，Rh和Ir配合物反应后，配体2容易形成双核配合物。
• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE
  申请人：Arvinas, Inc.

  公开号：US20180177750A1

  公开（公告）日：2018-06-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of enhancer of zeste homolog 2 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为增强子锁定同源2的调节剂而发挥作用。具体而言，本公开涉及包含一端为Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源2配体的双功能化合物，该配体与相应的E3泛素连接酶结合，另一端含有结合目标蛋白的基团，使目标蛋白靠近泛素连接酶以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由目标蛋白聚集或积累导致的疾病或紊乱。
• [EN] MTORC MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE MTORC ET LEURS UTILISATIONS
  申请人：AEOVIAN PHARMACEUTICALS INC

  公开号：WO2020154447A1

  公开（公告）日：2020-07-30

  Novel rapamycin analogs and uses thereof are disclosed herein. The rapamycin analogs of the present disclosure show increased mTORC1 specificity and lowered mTORC2 specificity relative to rapamycin.

  本文披露了新型雷帕霉素类似物及其用途。本公开的雷帕霉素类似物相对于雷帕霉素表现出增加的mTORC1特异性和降低的mTORC2特异性。
• NON-IONIC ARYL KETONE BASED POLYMERIC PHOTO-ACID GENERATORS
  申请人：International Business Machines Corporation

  公开号：US20180044459A1

  公开（公告）日：2018-02-15

  Non-ionic photo-acid generating (PAG) polymerizable monomers were prepared that contain a side chain sulfonate ester of an alpha-hydroxy aryl ketone. The aryl ketone group has a perfluorinated substituent alpha to the ketone carbonyl. The sulfur of the sulfonate ester is also directly linked to a fluorinated group. PAG polymers prepared from the PAG monomers release a strong sulfonic acid when exposed to high energy radiation such as deep UV or extreme UV light. The photo-generated sulfonic acid has a low diffusion rate in an exposed resist layer subjected to a post-exposure bake (PEB) at 100° C. to 150° C., resulting in formation of good line patterns after development.

  制备了含有α-羟基芳基酮的侧链磺酸酯的非离子光酸发生（PAG）可聚合单体。芳基酮基团在酮基团的α位有全氟取代基。磺酸酯的硫也直接连接到氟化基团。从这些PAG单体制备的PAG聚合物在暴露于高能辐射（如深紫外或极紫外光）时释放出强磺酸。在经过后曝光烘烤（PEB）处理（100°C至150°C）的暴露光刻胶层中，光生成的磺酸扩散速率较低，结果在显影后形成良好的线型图案。
• Photocatalytic nucleophilic addition of alcohols to styrenes in Markovnikov and anti-Markovnikov orientation
  作者：Martin Weiser、Sergej Hermann、Alexander Penner、Hans-Achim Wagenknecht

  DOI：10.3762/bjoc.11.62

  日期：——

  The nucleophilic addition of methanol and other alcohols to 1,1-diphenylethylene (1) and styrene (6) into the Markovnikov- and anti-Markovnikov-type products was selectively achieved with 1-(N,N-dimethylamino)pyrene (Py) and 1,7-dicyanoperylene-3,4:9,10-tetracarboxylic acid bisimide (PDI) as photoredox catalysts. The regioselectivity was controlled by the photocatalyst. For the reductive mode towards

  用1-（N，N-二甲基氨基）py（Py）选择性地将甲醇和其他醇类向1,1-二苯基乙烯（1）和苯乙烯（6）亲核加成到Markovnikov型和抗Markovnikov型产品中和1,7-二氰基亚戊基-3,4：9,10-四羧酸双酰亚胺（PDI）作为光氧化还原催化剂。区域选择性由光催化剂控制。对于向马尔科夫尼科夫型区域选择性的还原模式，Py被用作光催化剂，三乙胺被用作电子穿梭。该方法也用于分子内添加。对于向反马尔科夫尼科夫型区域选择性的氧化模式，PDI与Ph-SH作为添加剂一起应用。多种醇的光催化添加以良好至优异的产率获得了相应的产物。通过检测作为主要中间体的PDI自由基阴离子，并通过比较两个电子密度不同的分子内反应，支持了拟议的光催化电子转移机理。代表性的中流反应器实验可以大大缩短辐照时间，并可以将太阳光用作“绿色”光源。