N-烯丙基戊二酸 | 103980-33-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N-烯丙基戊二酸
• 英文名称: N-allyl glutaramic acid
• 英文别名: 5-Oxo-5-(prop-2-en-1-ylamino)pentanoic acid；5-oxo-5-(prop-2-enylamino)pentanoic acid
• CAS: 103980-33-2
• 化学式: C₈H₁₃NO₃
• mdl: MFCD06066213
• 分子量: 171.196
• InChiKey: VBAUQSXHAMRCSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  戊二酸酐 、 allylammonium chloride 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以74%的产率得到N-烯丙基戊二酸
  参考文献：
  名称：

  Glutamine analogues as potential antimalarials

  摘要：

  Various N-substituted derivatives of glutamine, asparagine, glutaramic, succinamic and maleamic acids have been synthesized and tested in vitro against Plasmodium falciparum. From these compounds, only the glutamine derivatives (1-3) were found to have low activity. Kinetic evaluation of 1-3 revealed that these compounds also act as competitive inhibitors of gamma-glutamyl transpeptidase (EC 2.3.2.2).

  DOI：

  10.1016/0223-5234(91)90030-q

文献信息

• TARGET MOLECULE ATTACHMENT TO SURFACES
  申请人：SURMODICS, INC.

  公开号：US20010014448A1

  公开（公告）日：2001-08-16

  Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.

  一种用于共价连接目标分子（例如核酸）到基质表面的方法和试剂组成物。试剂组成物包括能够共价结合到目标分子的基团。可选地，该组成物可以包含光敏基团，用于将试剂组成物附着到表面上。该试剂组成物可用于提供活化幻灯片，用于制备核酸微阵列。
• Target molecule attachment to surfaces
  申请人：Chappa A. Ralph

  公开号：US20050170427A1

  公开（公告）日：2005-08-04

  Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.

  一种用于共价连接目标分子（例如核酸）到基质表面的方法和试剂组合物。试剂组合物包括能够共价结合到目标分子的基团。可选地，组合物可以含有光反应基团，用于将试剂组合物连接到表面上。试剂组合物可用于提供激活的载玻片，用于制备核酸微阵列。
• US6465178B2
  申请人：——

  公开号：US6465178B2

  公开（公告）日：2002-10-15
• US7691787B2
  申请人：——

  公开号：US7691787B2

  公开（公告）日：2010-04-06
• [EN] TARGET MOLECULE ATTACHMENT TO SURFACES<br/>[FR] FIXATION DE MOLECULES CIBLES A DES SURFACES
  申请人：SURMODICS INC

  公开号：WO2000040593A2

  公开（公告）日：2000-07-13

  Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.